FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980783706> ?p ?o ?g. }

• W2980783706 endingPage "133" @default.
• W2980783706 startingPage "118" @default.
• W2980783706 abstract "Abstract Nerve regeneration is blocked after spinal cord injury (SCI) by a complex myelin-associated inhibitory (MAI) microenvironment in the lesion site; however, the underlying mechanisms are not fully understood. During the process of neural stem cell (NSC) differentiation, pathway inhibitors were added to quantitatively assess the effects on neuronal differentiation. Immunoprecipitation and lentivirus-induced overexpression were used to examine effects in vitro. In vivo, animal experiments and lineage tracing methods were used to identify nascent neurogenesis after SCI. In vitro results indicated that myelin inhibited neuronal differentiation by activating the epidermal growth factor receptor (EGFR)-extracellular-regulated kinase (ERK) signaling cascade. Subsequently, we found that tripartite motif (TRIM) 32, a neuronal fate-determining factor, was inhibited. Moreover, inhibition of EGFR-ERK promoted TRIM32 expression and enhanced neuronal differentiation in the presence of myelin. We further demonstrated that ERK interacts with TRIM32 to regulate neuronal differentiation. In vivo results indicated that EGFR-ERK blockade increased TRIM32 expression and promoted neurogenesis in the injured area, thus enhancing functional recovery after SCI. Our results showed that EGFR-ERK blockade antagonized MAI of neuronal differentiation of NSCs through regulation of TRIM32 by ERK. Collectively, these findings may provide potential new targets for SCI repair." @default.
• W2980783706 created "2019-10-25" @default.
• W2980783706 creator A5001098328 @default.
• W2980783706 creator A5001585514 @default.
• W2980783706 creator A5011403168 @default.
• W2980783706 creator A5013725970 @default.
• W2980783706 creator A5015204683 @default.
• W2980783706 creator A5015545152 @default.
• W2980783706 creator A5019147529 @default.
• W2980783706 creator A5025751238 @default.
• W2980783706 creator A5027345342 @default.
• W2980783706 creator A5034242409 @default.
• W2980783706 creator A5035734524 @default.
• W2980783706 creator A5037719922 @default.
• W2980783706 creator A5038604255 @default.
• W2980783706 creator A5041858499 @default.
• W2980783706 creator A5044004985 @default.
• W2980783706 creator A5054592678 @default.
• W2980783706 creator A5054982110 @default.
• W2980783706 creator A5057408888 @default.
• W2980783706 creator A5077604881 @default.
• W2980783706 creator A5078164975 @default.
• W2980783706 date "2019-10-17" @default.
• W2980783706 modified "2023-10-15" @default.
• W2980783706 title "Epidermal growth factor receptor-extracellular-regulated kinase blockade upregulates TRIM32 signaling cascade and promotes neurogenesis after spinal cord injury" @default.
• W2980783706 cites W1899468091 @default.
• W2980783706 cites W1934819143 @default.
• W2980783706 cites W1975724680 @default.
• W2980783706 cites W1976498439 @default.
• W2980783706 cites W1982737759 @default.
• W2980783706 cites W1983325630 @default.
• W2980783706 cites W1983712592 @default.
• W2980783706 cites W1990228542 @default.
• W2980783706 cites W1996967454 @default.
• W2980783706 cites W1998091512 @default.
• W2980783706 cites W2001027721 @default.
• W2980783706 cites W2012441637 @default.
• W2980783706 cites W2014484372 @default.
• W2980783706 cites W2018863770 @default.
• W2980783706 cites W2025902983 @default.
• W2980783706 cites W2034500742 @default.
• W2980783706 cites W2035936653 @default.
• W2980783706 cites W2042279121 @default.
• W2980783706 cites W2054201119 @default.
• W2980783706 cites W2060098193 @default.
• W2980783706 cites W2063459592 @default.
• W2980783706 cites W2080215345 @default.
• W2980783706 cites W2086345417 @default.
• W2980783706 cites W2094921364 @default.
• W2980783706 cites W2095963321 @default.
• W2980783706 cites W2099614676 @default.
• W2980783706 cites W2105616363 @default.
• W2980783706 cites W2106119346 @default.
• W2980783706 cites W2107589629 @default.
• W2980783706 cites W2116773729 @default.
• W2980783706 cites W2119216843 @default.
• W2980783706 cites W2128475302 @default.
• W2980783706 cites W2129588435 @default.
• W2980783706 cites W2131037087 @default.
• W2980783706 cites W2132424160 @default.
• W2980783706 cites W2142820864 @default.
• W2980783706 cites W2155126659 @default.
• W2980783706 cites W2164826784 @default.
• W2980783706 cites W2166430233 @default.
• W2980783706 cites W2395055872 @default.
• W2980783706 cites W2568379729 @default.
• W2980783706 cites W2583070640 @default.
• W2980783706 cites W2610035170 @default.
• W2980783706 cites W2616273892 @default.
• W2980783706 cites W2769155717 @default.
• W2980783706 cites W2902291355 @default.
• W2980783706 cites W598708682 @default.
• W2980783706 doi "https://doi.org/10.1002/stem.3097" @default.
• W2980783706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31621984" @default.
• W2980783706 hasPublicationYear "2019" @default.
• W2980783706 type Work @default.
• W2980783706 sameAs 2980783706 @default.
• W2980783706 citedByCount "15" @default.
• W2980783706 countsByYear W29807837062020 @default.
• W2980783706 countsByYear W29807837062021 @default.
• W2980783706 countsByYear W29807837062022 @default.
• W2980783706 countsByYear W29807837062023 @default.
• W2980783706 crossrefType "journal-article" @default.
• W2980783706 hasAuthorship W2980783706A5001098328 @default.
• W2980783706 hasAuthorship W2980783706A5001585514 @default.
• W2980783706 hasAuthorship W2980783706A5011403168 @default.
• W2980783706 hasAuthorship W2980783706A5013725970 @default.
• W2980783706 hasAuthorship W2980783706A5015204683 @default.
• W2980783706 hasAuthorship W2980783706A5015545152 @default.
• W2980783706 hasAuthorship W2980783706A5019147529 @default.
• W2980783706 hasAuthorship W2980783706A5025751238 @default.
• W2980783706 hasAuthorship W2980783706A5027345342 @default.
• W2980783706 hasAuthorship W2980783706A5034242409 @default.
• W2980783706 hasAuthorship W2980783706A5035734524 @default.
• W2980783706 hasAuthorship W2980783706A5037719922 @default.
• W2980783706 hasAuthorship W2980783706A5038604255 @default.
• W2980783706 hasAuthorship W2980783706A5041858499 @default.
• W2980783706 hasAuthorship W2980783706A5044004985 @default.

• next