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- W2980784189 abstract "Insulin resistance exerts a key role in the pathogenesis of obesity-related comorbidities. A growing body of evidence has pointed out that ectopic fat distribution, instead of total adiposity, is the main predictor of metabolic derangement in adults and children. Indeed, lipid accumulation in insulin-sensitive organs, such as liver and skeletal muscle, might impair insulin action leading to insulin resistance. In this chapter, we review the scientific evidence of association between ectopic fat deposition and reduced insulin resistance in youth. Moreover, we review the possible mechanisms that are involved in the pathogenesis of insulin resistance." @default.
- W2980784189 created "2019-10-25" @default.
- W2980784189 creator A5023870801 @default.
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- W2980784189 date "2019-10-15" @default.
- W2980784189 modified "2023-09-26" @default.
- W2980784189 title "Ectopic Fat and Insulin Resistance in Youth" @default.
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- W2980784189 doi "https://doi.org/10.1007/978-3-030-25057-7_10" @default.
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