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- W2980797156 abstract "Although soluble Aβ oligomer (AβO) might play a pivotal role in pathogenesis of Alzheimer's disease (AD), development of biomarker using detection of AβO might be limited due to its structural heterogeneity. Recently, we found the 56kDa soluble Aβ*56(Aβ*56) which is known to be involved in a very early sate of AD in human nasal secretion. The aim of this study is to explore diagnostic validity of Aβ*56 in nasal secretions in discriminating AD pathology. A total of 60 patients (N=20 for normal control (NC), amnestic mild cognitive impairment (aMCI), and AD) were included in the study. They were dichotomized using 18F-Flutemetamol amyloid positron emission tomography (PET) into with and without detectable amyloid burden. Level of Aβ*56 in nasal secretions were measured using immune blotting. Group differences in nasal Aβ*56 level were analyzed and correlation between nasal Aβ*56 level and mean standardized uptake value ratio were also conducted. In addition, receiver operating characteristic (ROC) analysis was conducted to evaluate the sensitivity and specificity of the nasal Aβ*56 level to discriminate amyloid pathology. There were no group differences in age, gender, and education. The nasal Aβ*56 level were significantly higher in aMCI and AD than NC group, but no group differences were found between aMCI and dementia. The ROC analysis showed an AUC (area under curve) value of 0.92, sensitivity of 90% and specificity of 86% in discriminating Amyloid positivity. The nasal Aβ*56 level also had a positive correlation with cortical Aβ deposition on 18F-Flutemetamol PET." @default.
- W2980797156 created "2019-10-25" @default.
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- W2980797156 date "2019-07-01" @default.
- W2980797156 modified "2023-10-07" @default.
- W2980797156 title "P4-545: DEVELOPMENT OF ALZHEIMER'S DISEASE BIOMARKER USING Aβ*56 SOLUBLE OLIGOMER IN HUMAN NASAL SECRETIONS" @default.
- W2980797156 doi "https://doi.org/10.1016/j.jalz.2019.08.092" @default.
- W2980797156 hasPublicationYear "2019" @default.
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