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• W2980816133 startingPage "285" @default.
• W2980816133 abstract "Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion." @default.
• W2980816133 created "2019-10-25" @default.
• W2980816133 creator A5004595871 @default.
• W2980816133 creator A5043407107 @default.
• W2980816133 creator A5059538840 @default.
• W2980816133 creator A5065128406 @default.
• W2980816133 date "2019-08-01" @default.
• W2980816133 modified "2023-09-23" @default.
• W2980816133 title "Dynamic Reorganization of Microtubule and Glioma Invasion." @default.
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