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• W2980842562 endingPage "102044" @default.
• W2980842562 startingPage "102044" @default.
• W2980842562 abstract "In many cases delusions in schizophrenia spectrum disorders (SSD) are driven by strong emotions such as feelings of paranoia or grandiosity. We refer to these extreme emotional experiences as psychotic affectivity. We hypothesized that increased structural connectivity of the supero-lateral medial forebrain bundle (slMFB), a major tract of the reward system, is associated with delusional psychotic affectivity. Forty-six patients with SSD and 44 healthy controls (HC) underwent diffusion weighted magnetic resonance imaging (DW-MRI)-scans. The slMFB and a comparison tract (corticospinal tract) were reconstructed using diffusion tensor imaging (DTI)-based tractography. Fractional anisotropy (FA) was sampled across the tracts. We used a mixed-model analyses of variance controlling for age and gender to compare FA of bilateral slMFB between SSD-patients and HC. Correlations of FA of bilateral slMFB and the PANSS-positive item delusions were calculated. In addition, FA was compared between three clinically homogeneous SSD-subgroups in terms of psychotic affectivity (severe, mild and no PA, sPA, mPA, nPA) and HC. FA of the slMFB did not differ between all SSD-patients and HC. In SSD-patients there was a positive correlation between delusions and FA in bilateral slMFB. Likewise, SSD-subgroups of psychotic affectivity and HC differed significantly in FA of the slMFB. Results were driven by higher FA in the right slMFB in sPA as compared to nPA and to HC. There was no significant effect for the comparison tract. In conclusion, increased structural connectivity of the slMFB may underlie delusional experiences of paranoia and grandiosity in SSD." @default.
• W2980842562 created "2019-10-25" @default.
• W2980842562 creator A5017882622 @default.
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• W2980842562 creator A5054901878 @default.
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• W2980842562 date "2019-01-01" @default.
• W2980842562 modified "2023-09-25" @default.
• W2980842562 title "Increased structural connectivity of the medial forebrain bundle in schizophrenia spectrum disorders is associated with delusions of paranoid threat and grandiosity" @default.
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• W2980842562 doi "https://doi.org/10.1016/j.nicl.2019.102044" @default.
• W2980842562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6978276" @default.
• W2980842562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31678911" @default.
• W2980842562 hasPublicationYear "2019" @default.

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