FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980851427> ?p ?o ?g. }

• W2980851427 endingPage "e0224108" @default.
• W2980851427 startingPage "e0224108" @default.
• W2980851427 abstract "The main control strategy for Ascaris lumbricoides is mass drug administration (especially with benzimidazoles), which can select strains of parasites resistant to treatment. Mutations in the beta-tubulin isotype-1 gene at codons 167, 198 and 200 have been linked to benzimidazole resistance in several nematodes. The mutation in codon 200 is the most frequent in different species of parasites, as previously observed in Necator americanus and Trichuris trichiura; however, this mutation has never been found in populations of A. lumbricoides. This study aimed to screen for single nucleotide polymorphisms (SNPs) in the beta-tubulin isotype-1 gene at codon 200 in A. lumbricoides. We developed a technique based on an amplification refractory mutation system (ARMS-PCR) for the analysis of 854 single A. lumbricoides eggs collected from 68 human stool samples from seven Brazilian states. We detected the mutation in codon 200 at a frequency of 0.5% (4/854). This is the first report of this mutation in A. lumbricoides. Although the observed frequency is low, its presence indicates that these parasite populations have the potential to develop high levels of resistance in the future. The methodology proposed here provides a powerful tool to screen for the emergence of anthelmintic resistance mutations in parasitic nematode populations." @default.
• W2980851427 created "2019-10-25" @default.
• W2980851427 creator A5014878161 @default.
• W2980851427 creator A5035207942 @default.
• W2980851427 creator A5043991288 @default.
• W2980851427 creator A5050289264 @default.
• W2980851427 creator A5050419929 @default.
• W2980851427 creator A5053091893 @default.
• W2980851427 creator A5068258144 @default.
• W2980851427 creator A5073564292 @default.
• W2980851427 creator A5086346656 @default.
• W2980851427 date "2019-10-17" @default.
• W2980851427 modified "2023-10-16" @default.
• W2980851427 title "First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides" @default.
• W2980851427 cites W162135498 @default.
• W2980851427 cites W1964375567 @default.
• W2980851427 cites W1970814605 @default.
• W2980851427 cites W1972646415 @default.
• W2980851427 cites W1979291126 @default.
• W2980851427 cites W2001482053 @default.
• W2980851427 cites W2007127410 @default.
• W2980851427 cites W2043375010 @default.
• W2980851427 cites W2048332168 @default.
• W2980851427 cites W2053482921 @default.
• W2980851427 cites W2059037153 @default.
• W2980851427 cites W2059186085 @default.
• W2980851427 cites W2061878700 @default.
• W2980851427 cites W2070516735 @default.
• W2980851427 cites W2071040688 @default.
• W2980851427 cites W2091868738 @default.
• W2980851427 cites W2095303104 @default.
• W2980851427 cites W2097690096 @default.
• W2980851427 cites W2119725164 @default.
• W2980851427 cites W2138270253 @default.
• W2980851427 cites W2151211884 @default.
• W2980851427 cites W2348988099 @default.
• W2980851427 cites W2470282944 @default.
• W2980851427 cites W2473578858 @default.
• W2980851427 cites W2563284854 @default.
• W2980851427 cites W2579171437 @default.
• W2980851427 cites W2615090386 @default.
• W2980851427 cites W2671985949 @default.
• W2980851427 cites W2734926251 @default.
• W2980851427 cites W2753029449 @default.
• W2980851427 cites W2804246952 @default.
• W2980851427 cites W2890332937 @default.
• W2980851427 cites W2890342156 @default.
• W2980851427 cites W2897597772 @default.
• W2980851427 cites W2913690503 @default.
• W2980851427 cites W4255751155 @default.
• W2980851427 cites W789791304 @default.
• W2980851427 doi "https://doi.org/10.1371/journal.pone.0224108" @default.
• W2980851427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6797262" @default.
• W2980851427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31622428" @default.
• W2980851427 hasPublicationYear "2019" @default.
• W2980851427 type Work @default.
• W2980851427 sameAs 2980851427 @default.
• W2980851427 citedByCount "27" @default.
• W2980851427 countsByYear W29808514272020 @default.
• W2980851427 countsByYear W29808514272021 @default.
• W2980851427 countsByYear W29808514272022 @default.
• W2980851427 countsByYear W29808514272023 @default.
• W2980851427 crossrefType "journal-article" @default.
• W2980851427 hasAuthorship W2980851427A5014878161 @default.
• W2980851427 hasAuthorship W2980851427A5035207942 @default.
• W2980851427 hasAuthorship W2980851427A5043991288 @default.
• W2980851427 hasAuthorship W2980851427A5050289264 @default.
• W2980851427 hasAuthorship W2980851427A5050419929 @default.
• W2980851427 hasAuthorship W2980851427A5053091893 @default.
• W2980851427 hasAuthorship W2980851427A5068258144 @default.
• W2980851427 hasAuthorship W2980851427A5073564292 @default.
• W2980851427 hasAuthorship W2980851427A5086346656 @default.
• W2980851427 hasBestOaLocation W29808514271 @default.
• W2980851427 hasConcept C104317684 @default.
• W2980851427 hasConcept C114851261 @default.
• W2980851427 hasConcept C135763542 @default.
• W2980851427 hasConcept C153209595 @default.
• W2980851427 hasConcept C165901193 @default.
• W2980851427 hasConcept C203014093 @default.
• W2980851427 hasConcept C2777047024 @default.
• W2980851427 hasConcept C2777364306 @default.
• W2980851427 hasConcept C501734568 @default.
• W2980851427 hasConcept C54355233 @default.
• W2980851427 hasConcept C86803240 @default.
• W2980851427 hasConceptScore W2980851427C104317684 @default.
• W2980851427 hasConceptScore W2980851427C114851261 @default.
• W2980851427 hasConceptScore W2980851427C135763542 @default.
• W2980851427 hasConceptScore W2980851427C153209595 @default.
• W2980851427 hasConceptScore W2980851427C165901193 @default.
• W2980851427 hasConceptScore W2980851427C203014093 @default.
• W2980851427 hasConceptScore W2980851427C2777047024 @default.
• W2980851427 hasConceptScore W2980851427C2777364306 @default.
• W2980851427 hasConceptScore W2980851427C501734568 @default.
• W2980851427 hasConceptScore W2980851427C54355233 @default.
• W2980851427 hasConceptScore W2980851427C86803240 @default.
• W2980851427 hasFunder F4320322980 @default.
• W2980851427 hasFunder F4320335239 @default.
• W2980851427 hasIssue "10" @default.

• next