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• W2980857580 abstract "Abstract Background: On the basis of a previous report of increased chronic myeloid leukemia (CML) risk following peptic ulcer, we hypothesized that chronic Helicobacter pylori infection could serve as a risk factor for CML. Methods: In a population-based, retrospective case–control study, we used Swedish registry data on 980 patients with CML and 4,960 age- and sex-matched controls to investigate associations between markers of previous infection with Helicobacter pylori and CML incidence. Results: Previous diagnoses of dyspepsia, gastritis or peptic ulcers, as well as previous proton pump inhibitor (PPI) medication, were all associated with a significantly increased risk of CML (RRs, 1.5–2.0; P = 0.0005–0.05). Meanwhile, neither inflammatory bowel disease nor intake of NSAIDs were associated with CML, indicating that it is not gastrointestinal ulcer or inflammation per se that influences risk. Conclusions: The consistent associations suggest a shared background between gastric conditions and CML, and strengthen the case that Helicobacter pylori could constitute this common risk factor. Impact: As the etiology of CML is practically unknown, and Helicobacter pylori could potentially be a therapeutic target, even this indirect evidence encourages further studies on the potential involvement of Helicobacter pylori in CML etiology." @default.
• W2980857580 created "2019-10-25" @default.
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• W2980857580 date "2020-01-01" @default.
• W2980857580 modified "2023-09-30" @default.
• W2980857580 title "Increased Risk of Chronic Myeloid Leukemia Following Gastric Conditions Indicating <i>Helicobacter pylori</i> Infection: A Case–Control Study" @default.
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• W2980857580 doi "https://doi.org/10.1158/1055-9965.epi-19-0758" @default.
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