Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980863485> ?p ?o ?g. }
- W2980863485 endingPage "e3000484" @default.
- W2980863485 startingPage "e3000484" @default.
- W2980863485 abstract "Accurate detection of extracellular chemical gradients is essential for many cellular behaviors. Gradient sensing is challenging for small cells, which can experience little difference in ligand concentrations on the up-gradient and down-gradient sides of the cell. Nevertheless, the tiny cells of the yeast Saccharomyces cerevisiae reliably decode gradients of extracellular pheromones to find their mates. By imaging the behavior of polarity factors and pheromone receptors, we quantified the accuracy of initial polarization during mating encounters. We found that cells bias the orientation of initial polarity up-gradient, even though they have unevenly distributed receptors. Uneven receptor density means that the gradient of ligand-bound receptors does not accurately reflect the external pheromone gradient. Nevertheless, yeast cells appear to avoid being misled by responding to the fraction of occupied receptors rather than simply the concentration of ligand-bound receptors. Such ratiometric sensing also serves to amplify the gradient of active G protein. However, this process is quite error-prone, and initial errors are corrected during a subsequent indecisive phase in which polarity clusters exhibit erratic mobile behavior." @default.
- W2980863485 created "2019-10-25" @default.
- W2980863485 creator A5002387944 @default.
- W2980863485 creator A5012884872 @default.
- W2980863485 creator A5019605898 @default.
- W2980863485 creator A5026964152 @default.
- W2980863485 creator A5049754077 @default.
- W2980863485 creator A5049869437 @default.
- W2980863485 creator A5061161969 @default.
- W2980863485 creator A5071511847 @default.
- W2980863485 date "2019-10-17" @default.
- W2980863485 modified "2023-10-11" @default.
- W2980863485 title "Ratiometric GPCR signaling enables directional sensing in yeast" @default.
- W2980863485 cites W1492253723 @default.
- W2980863485 cites W1494522948 @default.
- W2980863485 cites W1534431064 @default.
- W2980863485 cites W1584300199 @default.
- W2980863485 cites W1600299595 @default.
- W2980863485 cites W1859619881 @default.
- W2980863485 cites W1911465857 @default.
- W2980863485 cites W1944776925 @default.
- W2980863485 cites W1966072209 @default.
- W2980863485 cites W1967965852 @default.
- W2980863485 cites W1972238399 @default.
- W2980863485 cites W1975844203 @default.
- W2980863485 cites W1978423927 @default.
- W2980863485 cites W1979425962 @default.
- W2980863485 cites W1980292799 @default.
- W2980863485 cites W1984311414 @default.
- W2980863485 cites W1986149683 @default.
- W2980863485 cites W1995531673 @default.
- W2980863485 cites W2011249534 @default.
- W2980863485 cites W2013673237 @default.
- W2980863485 cites W2014587815 @default.
- W2980863485 cites W2016786372 @default.
- W2980863485 cites W2019125570 @default.
- W2980863485 cites W2019816658 @default.
- W2980863485 cites W2024184910 @default.
- W2980863485 cites W2028912942 @default.
- W2980863485 cites W2030213772 @default.
- W2980863485 cites W2031030809 @default.
- W2980863485 cites W2038659897 @default.
- W2980863485 cites W2039808072 @default.
- W2980863485 cites W2044252584 @default.
- W2980863485 cites W2047178927 @default.
- W2980863485 cites W2047770135 @default.
- W2980863485 cites W2049359083 @default.
- W2980863485 cites W2053796324 @default.
- W2980863485 cites W2054458841 @default.
- W2980863485 cites W2054522434 @default.
- W2980863485 cites W2063324492 @default.
- W2980863485 cites W2063976599 @default.
- W2980863485 cites W2080273350 @default.
- W2980863485 cites W2083908135 @default.
- W2980863485 cites W2086988705 @default.
- W2980863485 cites W2088401428 @default.
- W2980863485 cites W2094866737 @default.
- W2980863485 cites W2096830210 @default.
- W2980863485 cites W2103698933 @default.
- W2980863485 cites W2104524745 @default.
- W2980863485 cites W2111642295 @default.
- W2980863485 cites W2118936774 @default.
- W2980863485 cites W2119194326 @default.
- W2980863485 cites W2119496132 @default.
- W2980863485 cites W2122412269 @default.
- W2980863485 cites W2123256370 @default.
- W2980863485 cites W2124405153 @default.
- W2980863485 cites W2124650255 @default.
- W2980863485 cites W2129383789 @default.
- W2980863485 cites W2134848535 @default.
- W2980863485 cites W2140941733 @default.
- W2980863485 cites W2143325439 @default.
- W2980863485 cites W2145631191 @default.
- W2980863485 cites W2149063573 @default.
- W2980863485 cites W2156316864 @default.
- W2980863485 cites W2161296998 @default.
- W2980863485 cites W2161377323 @default.
- W2980863485 cites W2164495477 @default.
- W2980863485 cites W2166061717 @default.
- W2980863485 cites W2169333620 @default.
- W2980863485 cites W2169509065 @default.
- W2980863485 cites W2170631106 @default.
- W2980863485 cites W2174430707 @default.
- W2980863485 cites W2189808948 @default.
- W2980863485 cites W2310120462 @default.
- W2980863485 cites W2337770898 @default.
- W2980863485 cites W2521863806 @default.
- W2980863485 cites W2562538374 @default.
- W2980863485 cites W2587974254 @default.
- W2980863485 cites W2593960650 @default.
- W2980863485 cites W2606812145 @default.
- W2980863485 cites W2610808930 @default.
- W2980863485 cites W2619256223 @default.
- W2980863485 cites W2760866175 @default.
- W2980863485 cites W4254260042 @default.
- W2980863485 doi "https://doi.org/10.1371/journal.pbio.3000484" @default.
- W2980863485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6818790" @default.
- W2980863485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31622333" @default.