FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980865512> ?p ?o ?g. }

• W2980865512 abstract "Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associations is not always clear, and investigations to-date have often failed to replicate at the level of individual loci.Here, we undertook module- and region-based DNA methylation analyses of incident CVD in the Women's Health Initiative (WHI) and Framingham Heart Study Offspring Cohort (FHS) in order to find more robust epigenetic biomarkers for cardiovascular risk. We applied weighted gene correlation network analysis (WGCNA) and the Comb-p algorithm to find methylation modules and regions associated with incident CVD in the WHI dataset.We discovered two modules whose activation correlated with CVD risk and replicated across cohorts. One of these modules was enriched for development-related processes and overlaps strongly with epigenetic aging sites. For the other, we showed preliminary evidence for monocyte-specific effects and statistical links to cumulative exposure to traditional cardiovascular risk factors. Additionally, we found three regions (associated with the genes SLC9A1, SLC1A5, and TNRC6C) whose methylation associates with CVD risk.In sum, we present several epigenetic associations with incident CVD which reveal disease mechanisms related to development and monocyte biology. Furthermore, we show that epigenetic modules may act as a molecular readout of cumulative cardiovascular risk factor exposure, with implications for the improvement of clinical risk prediction." @default.
• W2980865512 created "2019-10-25" @default.
• W2980865512 creator A5003627453 @default.
• W2980865512 creator A5003794185 @default.
• W2980865512 creator A5018093575 @default.
• W2980865512 creator A5041357983 @default.
• W2980865512 creator A5051093934 @default.
• W2980865512 creator A5064192696 @default.
• W2980865512 date "2019-10-15" @default.
• W2980865512 modified "2023-10-16" @default.
• W2980865512 title "DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure" @default.
• W2980865512 cites W1480818485 @default.
• W2980865512 cites W1966327575 @default.
• W2980865512 cites W1970003449 @default.
• W2980865512 cites W1971440513 @default.
• W2980865512 cites W1974033269 @default.
• W2980865512 cites W1974047233 @default.
• W2980865512 cites W1990958459 @default.
• W2980865512 cites W2005357035 @default.
• W2980865512 cites W2017502278 @default.
• W2980865512 cites W2060492710 @default.
• W2980865512 cites W2060705109 @default.
• W2980865512 cites W2064766217 @default.
• W2980865512 cites W2066636897 @default.
• W2980865512 cites W2076154138 @default.
• W2980865512 cites W2077063343 @default.
• W2980865512 cites W2101870168 @default.
• W2980865512 cites W2112296601 @default.
• W2980865512 cites W2119883345 @default.
• W2980865512 cites W2120350873 @default.
• W2980865512 cites W2121091193 @default.
• W2980865512 cites W2127431419 @default.
• W2980865512 cites W2128016314 @default.
• W2980865512 cites W2129958809 @default.
• W2980865512 cites W2130752875 @default.
• W2980865512 cites W2131062132 @default.
• W2980865512 cites W2143954657 @default.
• W2980865512 cites W2145480803 @default.
• W2980865512 cites W2153424791 @default.
• W2980865512 cites W2162198924 @default.
• W2980865512 cites W2169556367 @default.
• W2980865512 cites W2207773426 @default.
• W2980865512 cites W2211287272 @default.
• W2980865512 cites W2238851414 @default.
• W2980865512 cites W2261451134 @default.
• W2980865512 cites W2279268491 @default.
• W2980865512 cites W2290627980 @default.
• W2980865512 cites W2316537321 @default.
• W2980865512 cites W2332043828 @default.
• W2980865512 cites W2467067181 @default.
• W2980865512 cites W2487548384 @default.
• W2980865512 cites W2518696140 @default.
• W2980865512 cites W2547809177 @default.
• W2980865512 cites W2549518011 @default.
• W2980865512 cites W2551476694 @default.
• W2980865512 cites W2560510482 @default.
• W2980865512 cites W2561301122 @default.
• W2980865512 cites W2567721002 @default.
• W2980865512 cites W2576832795 @default.
• W2980865512 cites W2587858407 @default.
• W2980865512 cites W2596440417 @default.
• W2980865512 cites W2613708736 @default.
• W2980865512 cites W2616483624 @default.
• W2980865512 cites W2618549787 @default.
• W2980865512 cites W2625632191 @default.
• W2980865512 cites W2746602488 @default.
• W2980865512 cites W2761275051 @default.
• W2980865512 cites W2768591422 @default.
• W2980865512 cites W2772553773 @default.
• W2980865512 cites W2778172945 @default.
• W2980865512 cites W2795486555 @default.
• W2980865512 cites W2805983714 @default.
• W2980865512 cites W2806102216 @default.
• W2980865512 cites W2919386822 @default.
• W2980865512 cites W2949100461 @default.
• W2980865512 cites W4292811746 @default.
• W2980865512 cites W4297674379 @default.
• W2980865512 doi "https://doi.org/10.1186/s13148-019-0705-2" @default.
• W2980865512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6792327" @default.
• W2980865512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31615550" @default.
• W2980865512 hasPublicationYear "2019" @default.
• W2980865512 type Work @default.
• W2980865512 sameAs 2980865512 @default.
• W2980865512 citedByCount "41" @default.
• W2980865512 countsByYear W29808655122019 @default.
• W2980865512 countsByYear W29808655122020 @default.
• W2980865512 countsByYear W29808655122021 @default.
• W2980865512 countsByYear W29808655122022 @default.
• W2980865512 countsByYear W29808655122023 @default.
• W2980865512 crossrefType "journal-article" @default.
• W2980865512 hasAuthorship W2980865512A5003627453 @default.
• W2980865512 hasAuthorship W2980865512A5003794185 @default.
• W2980865512 hasAuthorship W2980865512A5018093575 @default.
• W2980865512 hasAuthorship W2980865512A5041357983 @default.
• W2980865512 hasAuthorship W2980865512A5051093934 @default.
• W2980865512 hasAuthorship W2980865512A5064192696 @default.
• W2980865512 hasBestOaLocation W29808655121 @default.
• W2980865512 hasConcept C104317684 @default.
• W2980865512 hasConcept C111815664 @default.
• W2980865512 hasConcept C112672928 @default.

• next