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- W2980882190 abstract "APOE ε4 has been the most significant genetic risk factor for Alzheimer's disease (AD) and recent studies successfully unmasked effects of other loci by performing a stratified analysis with APOE-defined subgroups. Other factors, such as non-randomised case/control experiments, however, also can mask effects of unrevealed loci for AD. Here, we propose a post-hoc genome-wide association (GWA) analysis using matched subsets of samples. We first perform GWAS and re-performed APOE-genotype stratified analysis with different subset of samples selected by the proposed matching method. The post-hoc stratified GWAS analysis was applied to 3146 Korean subjects from Gwangju Alzheimer's & Related Dementia (GARD) cohort and identified several genome-wide suggestive loci for late onset Alzheimer's disease (LOAD). The analysis found enrichment for different Odds Ratio (OR) directions, of which the enrichments that differ between strata are of particular interest. For example, a larger number of risk alleles was found for APOE ε4 non-carrier, but a larger number of protective alleles for APOE ε4 carrier. The ranked lists will be made available for other researcher as resource. The functional annotation and pathway analysis for these loci found several interesting results." @default.
- W2980882190 created "2019-10-25" @default.
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- W2980882190 date "2019-07-01" @default.
- W2980882190 modified "2023-09-28" @default.
- W2980882190 title "P4-491: A SYSTEMATIC POST-HOC ANALYSIS WITH MATCHED SAMPLES FOR ALZHEIMER'S DISEASE IN A KOREAN POPULATION" @default.
- W2980882190 doi "https://doi.org/10.1016/j.jalz.2019.08.037" @default.
- W2980882190 hasPublicationYear "2019" @default.
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