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• W2980884086 endingPage "104368" @default.
• W2980884086 startingPage "104368" @default.
• W2980884086 abstract "Four new dibenzocyclooctadiene lignans, named heilaohusus A-D (1-4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6-12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC, NOESY and CD spectra. Among the known compounds, compounds 6 and 8-12 were isolated from this plant for the first time. All of compounds were evaluated for their cytotoxicity activities, compounds 3, 6 and 7 showed weak cytotoxicity against four human cancer cell lines (HepG-2, HCT-116, BGC-823 and Hela) with IC50 values range from 13.04 to 21.93 μM. Compounds 1 and 7 demonstrated potential anti-RA (rheumatoid arthritis) activity against RA-FLS cell line with IC50 values of 14.57 and 11.70 μM, respectively." @default.
• W2980884086 created "2019-10-25" @default.
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• W2980884086 date "2019-11-01" @default.
• W2980884086 modified "2023-10-14" @default.
• W2980884086 title "New Lignans from roots of Kadsura coccinea" @default.
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• W2980884086 doi "https://doi.org/10.1016/j.fitote.2019.104368" @default.
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