FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980885917> ?p ?o ?g. }

• W2980885917 abstract "ABSTRACT Tissue homeostasis is maintained by differentiated progeny of residential stem cells. Both extrinsic signals and intrinsic factors play critical roles in the proliferation and differentiation of adult intestinal stem cells (ISCs). However, how extrinsic signals are transduced into ISCs still remains unclear. Here, we find that heparan sulfate (HS), a class of glycosaminoglycan (GAG) chains, negatively regulates progenitor proliferation and differentiation to maintain midgut homeostasis under physiological conditions. Interestingly, HS depletion in progenitors results in inactivation of Decapentaplegic (Dpp) signaling. Dpp signal inactivation in progenitors resembles HS-deficient intestines. Ectopic Dpp signaling completely rescued the defects caused by HS depletion. Taken together, these data demonstrate that HS is required for Dpp signaling to maintain midgut homeostasis. Our results provide insight into the regulatory mechanisms of how extrinsic signals are transduced into stem cells to regulate their proliferation and differentiation." @default.
• W2980885917 created "2019-10-25" @default.
• W2980885917 creator A5000419703 @default.
• W2980885917 creator A5006126682 @default.
• W2980885917 creator A5043890343 @default.
• W2980885917 creator A5048977776 @default.
• W2980885917 creator A5063710804 @default.
• W2980885917 creator A5076388485 @default.
• W2980885917 creator A5077129573 @default.
• W2980885917 creator A5077860517 @default.
• W2980885917 date "2019-10-15" @default.
• W2980885917 modified "2023-09-28" @default.
• W2980885917 title "Heparan sulfate negatively regulates intestinal stem cell proliferation in <i>Drosophila</i> adult midgut" @default.
• W2980885917 cites W1566448969 @default.
• W2980885917 cites W1648692159 @default.
• W2980885917 cites W1964684127 @default.
• W2980885917 cites W1965078663 @default.
• W2980885917 cites W1965746541 @default.
• W2980885917 cites W1968112233 @default.
• W2980885917 cites W1968814136 @default.
• W2980885917 cites W1969837808 @default.
• W2980885917 cites W1971903348 @default.
• W2980885917 cites W1985234259 @default.
• W2980885917 cites W1985560624 @default.
• W2980885917 cites W1988533881 @default.
• W2980885917 cites W1993076246 @default.
• W2980885917 cites W1993081168 @default.
• W2980885917 cites W1999316583 @default.
• W2980885917 cites W2003038417 @default.
• W2980885917 cites W2005670087 @default.
• W2980885917 cites W2005984478 @default.
• W2980885917 cites W2008826947 @default.
• W2980885917 cites W2010605216 @default.
• W2980885917 cites W2013123192 @default.
• W2980885917 cites W2015909273 @default.
• W2980885917 cites W2017479183 @default.
• W2980885917 cites W2028133785 @default.
• W2980885917 cites W2028539250 @default.
• W2980885917 cites W2030896914 @default.
• W2980885917 cites W2034362820 @default.
• W2980885917 cites W2035997436 @default.
• W2980885917 cites W2037048003 @default.
• W2980885917 cites W2037598426 @default.
• W2980885917 cites W2039806395 @default.
• W2980885917 cites W2045066366 @default.
• W2980885917 cites W2051909115 @default.
• W2980885917 cites W2058169506 @default.
• W2980885917 cites W2065653828 @default.
• W2980885917 cites W2069401350 @default.
• W2980885917 cites W2070386387 @default.
• W2980885917 cites W2073239066 @default.
• W2980885917 cites W2073594767 @default.
• W2980885917 cites W2073609428 @default.
• W2980885917 cites W2073824091 @default.
• W2980885917 cites W2076912393 @default.
• W2980885917 cites W2079657320 @default.
• W2980885917 cites W2080574458 @default.
• W2980885917 cites W2087336633 @default.
• W2980885917 cites W2088702684 @default.
• W2980885917 cites W2090095287 @default.
• W2980885917 cites W2091718842 @default.
• W2980885917 cites W2091883691 @default.
• W2980885917 cites W2092728011 @default.
• W2980885917 cites W2097071197 @default.
• W2980885917 cites W2097637166 @default.
• W2980885917 cites W2099277272 @default.
• W2980885917 cites W2099991247 @default.
• W2980885917 cites W2102091298 @default.
• W2980885917 cites W2104869280 @default.
• W2980885917 cites W2105241495 @default.
• W2980885917 cites W2105575647 @default.
• W2980885917 cites W2106918615 @default.
• W2980885917 cites W2116233619 @default.
• W2980885917 cites W2117159794 @default.
• W2980885917 cites W2118655645 @default.
• W2980885917 cites W2119251208 @default.
• W2980885917 cites W2120525124 @default.
• W2980885917 cites W2132605861 @default.
• W2980885917 cites W2134735295 @default.
• W2980885917 cites W2139236445 @default.
• W2980885917 cites W2140261464 @default.
• W2980885917 cites W2141906259 @default.
• W2980885917 cites W2142018200 @default.
• W2980885917 cites W2142335737 @default.
• W2980885917 cites W2142360030 @default.
• W2980885917 cites W2146712325 @default.
• W2980885917 cites W2148158930 @default.
• W2980885917 cites W2149867086 @default.
• W2980885917 cites W2150250127 @default.
• W2980885917 cites W2150561062 @default.
• W2980885917 cites W2151170075 @default.
• W2980885917 cites W2152665254 @default.
• W2980885917 cites W2154124544 @default.
• W2980885917 cites W2156014566 @default.
• W2980885917 cites W2164874402 @default.
• W2980885917 cites W2169829977 @default.
• W2980885917 cites W2314712188 @default.
• W2980885917 cites W2396836231 @default.
• W2980885917 cites W2401016962 @default.
• W2980885917 cites W2519226103 @default.

• next