Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980887757> ?p ?o ?g. }
- W2980887757 endingPage "108245" @default.
- W2980887757 startingPage "108245" @default.
- W2980887757 abstract "Cholangiocarcinoma (CCA) is a highly malignant cancer of the bile duct, which has a five-year survival rate less than 5% due to a high metastasis rate and lack of therapeutic options. Although omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been shown to inhibit the proliferation of CCA cells, the effects on CCA metastasis have not been previously reported. In this study, we first assessed the proliferation, migration and invasion effects of n-3 PUFA-based fish oil on human CCA cells. Then, we investigated PUFA effects on metastasis in vivo by xenografting CCA cells into zebrafish larvae that overexpress a critical n-3 PUFA synthesis gene, Δ6 fatty acid desaturase. The results indicated that n-3 PUFA-based fish oil suppresses CCA cell growth, potentially by blocking the cell cycle at G2/M phase, and it inhibits migration and invasion potential with coincident downregulation of migration-related genes. Furthermore, zebrafish endogenous n-3 PUFAs appear to suppress CCA metastasis by inhibiting the expression of twist, a key regulator of tumor metastasis. Interestingly, only long chain n-3 PUFAs could inhibit the expression of twist in CCA cells. Together, our results suggest that n-3 PUFAs, especially DHA, may inhibit proliferation and metastasis of CCA cells by inhibiting the expression of twist." @default.
- W2980887757 created "2019-10-25" @default.
- W2980887757 creator A5007078925 @default.
- W2980887757 creator A5022789284 @default.
- W2980887757 creator A5030972103 @default.
- W2980887757 creator A5043590853 @default.
- W2980887757 creator A5064908662 @default.
- W2980887757 creator A5066741846 @default.
- W2980887757 creator A5079475592 @default.
- W2980887757 date "2019-12-01" @default.
- W2980887757 modified "2023-09-28" @default.
- W2980887757 title "Omega-3 polyunsaturated fatty acids suppress metastatic features of human cholangiocarcinoma cells by suppressing twist" @default.
- W2980887757 cites W1895462365 @default.
- W2980887757 cites W1919721665 @default.
- W2980887757 cites W1927039003 @default.
- W2980887757 cites W1969811404 @default.
- W2980887757 cites W1970145694 @default.
- W2980887757 cites W1972379535 @default.
- W2980887757 cites W1973944606 @default.
- W2980887757 cites W1994380103 @default.
- W2980887757 cites W1994766646 @default.
- W2980887757 cites W2012655434 @default.
- W2980887757 cites W2014475555 @default.
- W2980887757 cites W2015717700 @default.
- W2980887757 cites W2019236201 @default.
- W2980887757 cites W2026027723 @default.
- W2980887757 cites W2028821626 @default.
- W2980887757 cites W2032611940 @default.
- W2980887757 cites W2034269086 @default.
- W2980887757 cites W2039893343 @default.
- W2980887757 cites W2040913648 @default.
- W2980887757 cites W2041834835 @default.
- W2980887757 cites W2047463366 @default.
- W2980887757 cites W2059385151 @default.
- W2980887757 cites W2060068262 @default.
- W2980887757 cites W2063306428 @default.
- W2980887757 cites W2093614380 @default.
- W2980887757 cites W2096296897 @default.
- W2980887757 cites W2097011443 @default.
- W2980887757 cites W2099540110 @default.
- W2980887757 cites W2100592123 @default.
- W2980887757 cites W2107220802 @default.
- W2980887757 cites W2107697912 @default.
- W2980887757 cites W2111705756 @default.
- W2980887757 cites W2121453809 @default.
- W2980887757 cites W2121472083 @default.
- W2980887757 cites W2122339079 @default.
- W2980887757 cites W2123276507 @default.
- W2980887757 cites W2125518778 @default.
- W2980887757 cites W2125555008 @default.
- W2980887757 cites W2130228302 @default.
- W2980887757 cites W2132240483 @default.
- W2980887757 cites W2134328169 @default.
- W2980887757 cites W2136679865 @default.
- W2980887757 cites W2148676014 @default.
- W2980887757 cites W2151650153 @default.
- W2980887757 cites W2152002064 @default.
- W2980887757 cites W2158248594 @default.
- W2980887757 cites W2161084690 @default.
- W2980887757 cites W2168526937 @default.
- W2980887757 cites W2173425713 @default.
- W2980887757 cites W2309818502 @default.
- W2980887757 cites W2310360698 @default.
- W2980887757 cites W2493954387 @default.
- W2980887757 cites W2560087117 @default.
- W2980887757 cites W2581710157 @default.
- W2980887757 cites W2588953020 @default.
- W2980887757 cites W2614388893 @default.
- W2980887757 cites W2752048759 @default.
- W2980887757 cites W2763492611 @default.
- W2980887757 cites W2781380376 @default.
- W2980887757 cites W2811217156 @default.
- W2980887757 doi "https://doi.org/10.1016/j.jnutbio.2019.108245" @default.
- W2980887757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31678746" @default.
- W2980887757 hasPublicationYear "2019" @default.
- W2980887757 type Work @default.
- W2980887757 sameAs 2980887757 @default.
- W2980887757 citedByCount "3" @default.
- W2980887757 countsByYear W29808877572020 @default.
- W2980887757 countsByYear W29808877572021 @default.
- W2980887757 crossrefType "journal-article" @default.
- W2980887757 hasAuthorship W2980887757A5007078925 @default.
- W2980887757 hasAuthorship W2980887757A5022789284 @default.
- W2980887757 hasAuthorship W2980887757A5030972103 @default.
- W2980887757 hasAuthorship W2980887757A5043590853 @default.
- W2980887757 hasAuthorship W2980887757A5064908662 @default.
- W2980887757 hasAuthorship W2980887757A5066741846 @default.
- W2980887757 hasAuthorship W2980887757A5079475592 @default.
- W2980887757 hasConcept C104317684 @default.
- W2980887757 hasConcept C121608353 @default.
- W2980887757 hasConcept C137620995 @default.
- W2980887757 hasConcept C185592680 @default.
- W2980887757 hasConcept C19038510 @default.
- W2980887757 hasConcept C2776878037 @default.
- W2980887757 hasConcept C2779013556 @default.
- W2980887757 hasConcept C2779946292 @default.
- W2980887757 hasConcept C2909208804 @default.
- W2980887757 hasConcept C502942594 @default.