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- W2980894247 abstract "Abstract ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism highly expressed in liver, metabolizes 10-formyltetrahydrofolate to produce tetrahydrofolate (THF). This reaction might have a regulatory function towards reduced folate pools, de novo purine biosynthesis, and the flux of folate-bound methyl groups. To understand the role of the enzyme in cellular metabolism, Aldh1l1 −/− mice were generated using an ES cell clone (C57BL/6N background) from KOMP repository. Though Aldh1l1 −/− mice were viable and did not have an apparent phenotype, metabolomic analysis indicated that they had metabolic signs of folate deficiency. Specifically, the intermediate of the histidine degradation pathway and a marker of folate deficiency, formiminoglutamate, was increased more than 15-fold in livers of Aldh1l1 −/− mice. At the same time, blood folate levels were not changed and the total folate pool in the liver was decreased by only 20%. A two-fold decrease in glycine and a strong drop in glycine conjugates, a likely result of glycine shortage, were also observed in Aldh1l1 −/− mice. Our study indicates that in the absence of ALDH1L1 enzyme, 10-formyl-THF cannot be efficiently metabolized in the liver. This leads to the decrease in THF causing reduced generation of glycine from serine and impaired histidine degradation, two pathways strictly dependent on THF." @default.
- W2980894247 created "2019-10-25" @default.
- W2980894247 creator A5003153494 @default.
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- W2980894247 date "2019-10-17" @default.
- W2980894247 modified "2023-10-18" @default.
- W2980894247 title "Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver" @default.
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- W2980894247 doi "https://doi.org/10.1038/s41598-019-51397-1" @default.
- W2980894247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6797707" @default.
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- W2980894247 hasPublicationYear "2019" @default.
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