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• W2980904810 abstract "For the management of Parkinson’s disease (PD) the concept of forced exercise (FE) has drawn interest. In PD subjects, the FE executed with lower limbs has been shown to lessen symptoms and to promote brain adaptive changes. Our study is aimed to investigate the effect of an upper limb exercise, conceptually comparable to the FE, in PD. Upper limb exercise was achieved in sitting position by using a specially designed device (Angel’s Wings ®). Clinical data, computerized dynamic posturography, magnetic resonance imaging (MRI) (resting state MRI, Arterial Spin Labeling) and neuropsychological tests were used before and after 2-months exercise training. We found a significant long-lasting improvement in UPDRS-III and cognitive scales, along with improvement in balance and postural control (better alignment of the gravity centre, improvement in weight symmetry and in anticipatory motor strategies). Computerized dynamic posturography pointed out an enhanced central ability to integrate the vestibular signals with afferents from other sensory systems. Neuroimaging analyses after 2-months exercise training showed, with respect to pre-training condition, many changes. An increase of the cerebral blood flow was evident in left primary motor cortex (M1), left supplementary motor cortical area and left cerebellar cortex. The bilateral globus pallidus showed an increased functional connectivity to the right central operculum, right posterior cingulate gyrus and left sensorimotor cortex. Seed-To-Voxel Analysis demonstrated a functional connectivity between M1 and left superior frontal gyrus. Left Crus II showed strengthened connections with left pre rolandic area, left post rolandic area, and left supramarginal area. These findings likely reflect compensatory mechanisms to the neuropathological hallmark of PD. Overall, our results show that this upper limb exercise model, conceptually comparable to the FE already tested in the lower limbs, leads to a global improvement (involving non-exercised limbs) likely consistent with the functional changes observed in the central nervous system." @default.
• W2980904810 created "2019-10-25" @default.
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• W2980904810 date "2019-10-15" @default.
• W2980904810 modified "2023-09-27" @default.
• W2980904810 title "Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson’s Disease" @default.
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• W2980904810 doi "https://doi.org/10.3389/fnhum.2019.00350" @default.
• W2980904810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6843060" @default.
• W2980904810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31749690" @default.
• W2980904810 hasPublicationYear "2019" @default.
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