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• W2980910050 abstract "Abstract The primeval function of the mammalian hippocampus (HPC) remains uncertain. Implicated in learning and memory, spatial navigation, and neuropsychological disorders, evolutionary theory suggests that the HPC evolved from a primeval chemosensory epithelium. Internal sensing deficits in patients with HPC lesions argue that internal sensing may be conserved in higher vertebrates. We studied the expression of 250 endocrine receptors in mouse brain. Key findings are (i) the proportions and levels of endocrine receptor expression in the HPC are significantly higher than in all other comparable brain regions. (ii) Surprisingly, the distribution of endocrine receptor expression within mouse HPC was found to be highly structured: receptors signaling ‘challenge’ are segregated in dentate gyrus (DG), whereas those signaling ‘sufficiency’ are principally found in cornu ammonis (CA) regions. Selective expression of endocrine receptors in the HPC argues that internal sensing remains a core feature of hippocampal function. Further, we report that ligands of DG receptors predominantly inhibit both synaptic potentiation and neurogenesis, whereas CA receptor ligands conversely promote both synaptic potentiation and neurogenesis. These findings suggest that the hippocampus acts as an integrator of body status, extending its role in context-dependent memory encoding from ‘where’ and ‘when’ to ‘how I feel’. Implications for anxiety and depression are discussed." @default.
• W2980910050 created "2019-10-25" @default.
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• W2980910050 date "2019-10-18" @default.
• W2980910050 modified "2023-10-16" @default.
• W2980910050 title "The interoceptive hippocampus: mouse brain endocrine receptor expression highlights a dentate gyrus (DG)–cornu ammonis (CA) challenge– sufficiency axis" @default.
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• W2980910050 doi "https://doi.org/10.1101/802975" @default.
• W2980910050 hasPublicationYear "2019" @default.
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