FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980918949> ?p ?o ?g. }

• W2980918949 endingPage "709" @default.
• W2980918949 startingPage "701" @default.
• W2980918949 abstract "ABSTRACT Background: Hemophagocytic lymphohistiocytosis (HLH), an uncontrolled overactivation of the immune system, is well characterized in pediatric patients, yet, much less is known about this life-threatening condition in adult patients. As HLH is often complicated by organ failure, patients will require admission to the intensive care unit for organ support therapy. However, recognition of HLH patients in the intensive care unit (ICU) is challenged by the clinical overlap with sepsis. Here, we analyze HLH patients to better understand its clinical presentation, diagnosis, and treatment. Methods: For the purpose of this retrospective observational study, we searched for suspected and diagnosed adult HLH of all patients admitted to at least one adult surgical, anesthesiological or medical ICU between January 2006 and August 2018 at the university hospital Charité — Universitätsmedizin Berlin. All cases were reviewed by two HLH experts, who confirmed or declined the diagnosis. Results: Of 6,340 ICU patients with ferritin measurement, 40 suffered from HLH (0.63%). Of these, in-hospital mortality was 60.0% over all cases, which was highest in malignancy-associated HLH (71.4%). Infections were identified as most common triggers (42.5%). A variety of 19 different treatment strategies were applied. Non-survivors showed higher ferritin at diagnosis compared with survivors ( P = 0.021), which was also seen in multivariable analyses. A minimum ferritin of 4083 μg/L after diagnosis was most predictive for 30-day mortality (AUC 0.888, 95% CI 0.771–1.000; sensitivity 93.8%, specificity 78.9%). Conclusions: Mortality in adult HLH patients in the ICU is high, particularly in malignancy-associated HLH. Infections are the most frequent HLH triggers in critically ill patients. At present, there is no standardized treatment for HLH in adult patients available. Assessment of ferritin is valuable for diagnosis, prognosis, and treatment monitoring. Trial registration: The study was registered with www.ClinicalTrials.gov (NCT02854943) on August 1, 2016." @default.
• W2980918949 created "2019-10-25" @default.
• W2980918949 creator A5000741825 @default.
• W2980918949 creator A5003411826 @default.
• W2980918949 creator A5016186200 @default.
• W2980918949 creator A5027882274 @default.
• W2980918949 creator A5037014310 @default.
• W2980918949 creator A5042435910 @default.
• W2980918949 creator A5046117818 @default.
• W2980918949 creator A5061408567 @default.
• W2980918949 creator A5063781065 @default.
• W2980918949 creator A5065061514 @default.
• W2980918949 creator A5070260720 @default.
• W2980918949 creator A5077534980 @default.
• W2980918949 date "2019-10-15" @default.
• W2980918949 modified "2023-10-15" @default.
• W2980918949 title "Hemophagocytic Lymphohistiocytosis in Critically Ill Patients" @default.
• W2980918949 cites W1505641753 @default.
• W2980918949 cites W1925777576 @default.
• W2980918949 cites W1988483602 @default.
• W2980918949 cites W2003202212 @default.
• W2980918949 cites W2043530968 @default.
• W2980918949 cites W2055476027 @default.
• W2980918949 cites W2083284484 @default.
• W2980918949 cites W2083452683 @default.
• W2980918949 cites W2085128602 @default.
• W2980918949 cites W2144510654 @default.
• W2980918949 cites W2155477306 @default.
• W2980918949 cites W2162251899 @default.
• W2980918949 cites W2162436197 @default.
• W2980918949 cites W2163067702 @default.
• W2980918949 cites W2163583822 @default.
• W2980918949 cites W2177407033 @default.
• W2980918949 cites W2235087472 @default.
• W2980918949 cites W2282446718 @default.
• W2980918949 cites W2295521935 @default.
• W2980918949 cites W2327674242 @default.
• W2980918949 cites W2484430354 @default.
• W2980918949 cites W2601392452 @default.
• W2980918949 cites W2756170974 @default.
• W2980918949 cites W2765913410 @default.
• W2980918949 cites W2785196859 @default.
• W2980918949 cites W2886583401 @default.
• W2980918949 cites W2913532246 @default.
• W2980918949 cites W2936019126 @default.
• W2980918949 cites W2954908348 @default.
• W2980918949 cites W298983351 @default.
• W2980918949 cites W2996830183 @default.
• W2980918949 doi "https://doi.org/10.1097/shk.0000000000001454" @default.
• W2980918949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31626037" @default.
• W2980918949 hasPublicationYear "2019" @default.
• W2980918949 type Work @default.
• W2980918949 sameAs 2980918949 @default.
• W2980918949 citedByCount "21" @default.
• W2980918949 countsByYear W29809189492020 @default.
• W2980918949 countsByYear W29809189492021 @default.
• W2980918949 countsByYear W29809189492022 @default.
• W2980918949 countsByYear W29809189492023 @default.
• W2980918949 crossrefType "journal-article" @default.
• W2980918949 hasAuthorship W2980918949A5000741825 @default.
• W2980918949 hasAuthorship W2980918949A5003411826 @default.
• W2980918949 hasAuthorship W2980918949A5016186200 @default.
• W2980918949 hasAuthorship W2980918949A5027882274 @default.
• W2980918949 hasAuthorship W2980918949A5037014310 @default.
• W2980918949 hasAuthorship W2980918949A5042435910 @default.
• W2980918949 hasAuthorship W2980918949A5046117818 @default.
• W2980918949 hasAuthorship W2980918949A5061408567 @default.
• W2980918949 hasAuthorship W2980918949A5063781065 @default.
• W2980918949 hasAuthorship W2980918949A5065061514 @default.
• W2980918949 hasAuthorship W2980918949A5070260720 @default.
• W2980918949 hasAuthorship W2980918949A5077534980 @default.
• W2980918949 hasBestOaLocation W29809189491 @default.
• W2980918949 hasConcept C126322002 @default.
• W2980918949 hasConcept C167135981 @default.
• W2980918949 hasConcept C177713679 @default.
• W2980918949 hasConcept C187212893 @default.
• W2980918949 hasConcept C2776376669 @default.
• W2980918949 hasConcept C2778319317 @default.
• W2980918949 hasConcept C2778384902 @default.
• W2980918949 hasConcept C2778426790 @default.
• W2980918949 hasConcept C2779079688 @default.
• W2980918949 hasConcept C2779134260 @default.
• W2980918949 hasConcept C2779399171 @default.
• W2980918949 hasConcept C2987404301 @default.
• W2980918949 hasConcept C71924100 @default.
• W2980918949 hasConceptScore W2980918949C126322002 @default.
• W2980918949 hasConceptScore W2980918949C167135981 @default.
• W2980918949 hasConceptScore W2980918949C177713679 @default.
• W2980918949 hasConceptScore W2980918949C187212893 @default.
• W2980918949 hasConceptScore W2980918949C2776376669 @default.
• W2980918949 hasConceptScore W2980918949C2778319317 @default.
• W2980918949 hasConceptScore W2980918949C2778384902 @default.
• W2980918949 hasConceptScore W2980918949C2778426790 @default.
• W2980918949 hasConceptScore W2980918949C2779079688 @default.
• W2980918949 hasConceptScore W2980918949C2779134260 @default.
• W2980918949 hasConceptScore W2980918949C2779399171 @default.
• W2980918949 hasConceptScore W2980918949C2987404301 @default.
• W2980918949 hasConceptScore W2980918949C71924100 @default.

• next