Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980923306> ?p ?o ?g. }
- W2980923306 abstract "Historically, interleukin-2 (IL-2) was first described as an immunostimulatory factor that supports the expansion of activated effector T cells. A layer of sophistication arose when regulatory CD4+ T lymphocytes (Tregs) were shown to require IL-2 for their development, homeostasis, and immunosuppressive functions. Fundamental distinctions in the nature and spatiotemporal expression patterns of IL-2 receptor subunits on naive/memory/effector T cells versus Tregs are now being exploited to manipulate the immunomodulatory effects of IL-2 for therapeutic purposes. Although high-dose IL-2 administration has yielded discrete clinical responses, low-dose IL-2 as well as innovative strategies based on IL-2 derivatives, including muteins, immunocomplexes, and immunocytokines, are being explored to therapeutically enhance or inhibit the immune response." @default.
- W2980923306 created "2019-10-25" @default.
- W2980923306 creator A5001202151 @default.
- W2980923306 creator A5006320965 @default.
- W2980923306 creator A5075296559 @default.
- W2980923306 creator A5084255907 @default.
- W2980923306 creator A5087910636 @default.
- W2980923306 date "2019-10-14" @default.
- W2980923306 modified "2023-10-17" @default.
- W2980923306 title "Effects of interleukin-2 in immunostimulation and immunosuppression" @default.
- W2980923306 cites W1486722793 @default.
- W2980923306 cites W1488390118 @default.
- W2980923306 cites W1499151513 @default.
- W2980923306 cites W1544808474 @default.
- W2980923306 cites W1547257472 @default.
- W2980923306 cites W1566445646 @default.
- W2980923306 cites W1567420244 @default.
- W2980923306 cites W1568663209 @default.
- W2980923306 cites W1587765371 @default.
- W2980923306 cites W1610775872 @default.
- W2980923306 cites W1807143116 @default.
- W2980923306 cites W1875544409 @default.
- W2980923306 cites W1878828051 @default.
- W2980923306 cites W1912001846 @default.
- W2980923306 cites W1918737925 @default.
- W2980923306 cites W1946393286 @default.
- W2980923306 cites W1950572133 @default.
- W2980923306 cites W1970246068 @default.
- W2980923306 cites W1971992050 @default.
- W2980923306 cites W1976355501 @default.
- W2980923306 cites W1976827943 @default.
- W2980923306 cites W1977304999 @default.
- W2980923306 cites W1977680996 @default.
- W2980923306 cites W1981597823 @default.
- W2980923306 cites W1982051091 @default.
- W2980923306 cites W1982696151 @default.
- W2980923306 cites W1986004077 @default.
- W2980923306 cites W1988177782 @default.
- W2980923306 cites W1988974159 @default.
- W2980923306 cites W1990555844 @default.
- W2980923306 cites W1990602451 @default.
- W2980923306 cites W1991036879 @default.
- W2980923306 cites W1993355276 @default.
- W2980923306 cites W1993426597 @default.
- W2980923306 cites W1996642272 @default.
- W2980923306 cites W1998298742 @default.
- W2980923306 cites W2000208875 @default.
- W2980923306 cites W2000869878 @default.
- W2980923306 cites W2005154465 @default.
- W2980923306 cites W2009420231 @default.
- W2980923306 cites W2010462935 @default.
- W2980923306 cites W2011738951 @default.
- W2980923306 cites W2012628829 @default.
- W2980923306 cites W2013495037 @default.
- W2980923306 cites W2017144261 @default.
- W2980923306 cites W2018931661 @default.
- W2980923306 cites W2020304403 @default.
- W2980923306 cites W2020976328 @default.
- W2980923306 cites W2021428880 @default.
- W2980923306 cites W2022373534 @default.
- W2980923306 cites W2027268096 @default.
- W2980923306 cites W2028597547 @default.
- W2980923306 cites W2035069582 @default.
- W2980923306 cites W2036160208 @default.
- W2980923306 cites W2046887547 @default.
- W2980923306 cites W2049237389 @default.
- W2980923306 cites W2049345643 @default.
- W2980923306 cites W2049808194 @default.
- W2980923306 cites W2051636382 @default.
- W2980923306 cites W2051962533 @default.
- W2980923306 cites W2053330214 @default.
- W2980923306 cites W2054363200 @default.
- W2980923306 cites W2059313411 @default.
- W2980923306 cites W2062080828 @default.
- W2980923306 cites W2062738834 @default.
- W2980923306 cites W2065395562 @default.
- W2980923306 cites W2067903176 @default.
- W2980923306 cites W2068639447 @default.
- W2980923306 cites W2070843905 @default.
- W2980923306 cites W2073128146 @default.
- W2980923306 cites W2073672027 @default.
- W2980923306 cites W2076338812 @default.
- W2980923306 cites W2076971074 @default.
- W2980923306 cites W2079721061 @default.
- W2980923306 cites W2080663614 @default.
- W2980923306 cites W2084560238 @default.
- W2980923306 cites W2085106134 @default.
- W2980923306 cites W2085918020 @default.
- W2980923306 cites W2086030126 @default.
- W2980923306 cites W2086143621 @default.
- W2980923306 cites W2087998194 @default.
- W2980923306 cites W2088391922 @default.
- W2980923306 cites W2090242584 @default.
- W2980923306 cites W2092931465 @default.
- W2980923306 cites W2092941122 @default.
- W2980923306 cites W2096619429 @default.
- W2980923306 cites W2097811455 @default.
- W2980923306 cites W2098136315 @default.
- W2980923306 cites W2099050377 @default.
- W2980923306 cites W2100083914 @default.