FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980934935> ?p ?o ?g. }

• W2980934935 endingPage "457" @default.
• W2980934935 startingPage "442" @default.
• W2980934935 abstract "Keratin degradation is of great interest for converting agro-industrial waste into bioactive peptides and is directly relevant for understanding the pathogenesis of superficial infections caused by dermatophytes. However, the mechanism of this process remains unclear. Here, we obtained the complete genome sequence of a feather-degrading, extremely thermophilic bacterium, Fervidobacterium islandicum AW-1 and performed bioinformatics-based functional annotation. Reverse transcription PCR revealed that 57 putative protease-encoding genes were differentially expressed in substrate-dependent manners. Consequently, 16 candidate genes were highly expressed under starvation conditions, when keratin degradation begun. Subsequently, the dynamic expression profiles of these 16 selected genes in response to feathers, as determined via quantitative real-time PCR, suggested that they included four metalloproteases and two peptidases including an ATP-dependent serine protease, all of which might act as key players in feather decomposition. Furthermore, in vitro keratinolytic assays supported the notion that recombinant enzymes enhanced the decomposition of feathers in the presence of cell extracts. Therefore, our genome-based systematic and dynamic expression profiling demonstrated that these identified metalloproteases together with two additional peptidases might be primarily associated with the decomposition of native feathers, suggesting that keratin degradation can be achieved via non-canonical catalysis of several membrane-associated metalloproteases in cooperation with cytosolic proteases." @default.
• W2980934935 created "2019-10-25" @default.
• W2980934935 creator A5011206327 @default.
• W2980934935 creator A5024769260 @default.
• W2980934935 creator A5052320199 @default.
• W2980934935 creator A5065872525 @default.
• W2980934935 creator A5070586345 @default.
• W2980934935 creator A5074912511 @default.
• W2980934935 creator A5087434564 @default.
• W2980934935 date "2019-10-15" @default.
• W2980934935 modified "2023-10-17" @default.
• W2980934935 title "Identification of keratinases from <i>Fervidobacterium islandicum</i> AW‐1 using dynamic gene expression profiling" @default.
• W2980934935 cites W126109032 @default.
• W2980934935 cites W1479734540 @default.
• W2980934935 cites W1486955981 @default.
• W2980934935 cites W1505724173 @default.
• W2980934935 cites W1516656431 @default.
• W2980934935 cites W1520821142 @default.
• W2980934935 cites W1570270309 @default.
• W2980934935 cites W1574063353 @default.
• W2980934935 cites W1971059401 @default.
• W2980934935 cites W1973970980 @default.
• W2980934935 cites W1977415279 @default.
• W2980934935 cites W1977493318 @default.
• W2980934935 cites W1983403167 @default.
• W2980934935 cites W1983425999 @default.
• W2980934935 cites W1986784933 @default.
• W2980934935 cites W1991409400 @default.
• W2980934935 cites W1994195954 @default.
• W2980934935 cites W1995778514 @default.
• W2980934935 cites W1996498312 @default.
• W2980934935 cites W2006370393 @default.
• W2980934935 cites W2009393104 @default.
• W2980934935 cites W2010458649 @default.
• W2980934935 cites W2013129766 @default.
• W2980934935 cites W2016979203 @default.
• W2980934935 cites W2023520898 @default.
• W2980934935 cites W2030956456 @default.
• W2980934935 cites W2034548160 @default.
• W2980934935 cites W2035457590 @default.
• W2980934935 cites W2041768492 @default.
• W2980934935 cites W2041887914 @default.
• W2980934935 cites W2051228317 @default.
• W2980934935 cites W2051551911 @default.
• W2980934935 cites W2051851016 @default.
• W2980934935 cites W2065139915 @default.
• W2980934935 cites W2077610871 @default.
• W2980934935 cites W2083661787 @default.
• W2980934935 cites W2088790513 @default.
• W2980934935 cites W2089442156 @default.
• W2980934935 cites W2090981936 @default.
• W2980934935 cites W2093940486 @default.
• W2980934935 cites W2094201044 @default.
• W2980934935 cites W2095206099 @default.
• W2980934935 cites W2099540110 @default.
• W2980934935 cites W2104178065 @default.
• W2980934935 cites W2107277218 @default.
• W2980934935 cites W2112966595 @default.
• W2980934935 cites W2113201292 @default.
• W2980934935 cites W2113205719 @default.
• W2980934935 cites W2125463837 @default.
• W2980934935 cites W2129937209 @default.
• W2980934935 cites W2132341951 @default.
• W2980934935 cites W2133790733 @default.
• W2980934935 cites W2148907971 @default.
• W2980934935 cites W2152770371 @default.
• W2980934935 cites W2164154943 @default.
• W2980934935 cites W2166406784 @default.
• W2980934935 cites W2168420558 @default.
• W2980934935 cites W2175796632 @default.
• W2980934935 cites W2223752691 @default.
• W2980934935 cites W2235411149 @default.
• W2980934935 cites W2330919216 @default.
• W2980934935 cites W2589836012 @default.
• W2980934935 cites W2592633878 @default.
• W2980934935 cites W2769449671 @default.
• W2980934935 cites W2769778960 @default.
• W2980934935 cites W2792200850 @default.
• W2980934935 cites W2899799080 @default.
• W2980934935 cites W2921228645 @default.
• W2980934935 cites W4234152304 @default.
• W2980934935 doi "https://doi.org/10.1111/1751-7915.13493" @default.
• W2980934935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7017815" @default.
• W2980934935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31613061" @default.
• W2980934935 hasPublicationYear "2019" @default.
• W2980934935 type Work @default.
• W2980934935 sameAs 2980934935 @default.
• W2980934935 citedByCount "19" @default.
• W2980934935 countsByYear W29809349352020 @default.
• W2980934935 countsByYear W29809349352021 @default.
• W2980934935 countsByYear W29809349352022 @default.
• W2980934935 countsByYear W29809349352023 @default.
• W2980934935 crossrefType "journal-article" @default.
• W2980934935 hasAuthorship W2980934935A5011206327 @default.
• W2980934935 hasAuthorship W2980934935A5024769260 @default.
• W2980934935 hasAuthorship W2980934935A5052320199 @default.
• W2980934935 hasAuthorship W2980934935A5065872525 @default.
• W2980934935 hasAuthorship W2980934935A5070586345 @default.

• next