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- W2980937299 abstract "We investigated the neural correlates of cognitive dysfunction in patients with Alzheimer's disease (AD)-related cognitive impairment (ADCI) and those with Lewy bodies-related cognitive impairment (LBCI). We enrolled 216 ADCI patients, 183 LBCI patients and 30 controls from January 2014 to April 2017. Cortical thickness and diffusion tensor imaging analyses were performed to correlate gray matter (GM) and white matter (WM) abnormalities to cognitive composite scores for memory, visuospatial, and attention/executive domains in the ADCI spectrum (ADCI patients and controls) and the LBCI spectrum (LBCI patients and controls) separately. Regarding the ADCI spectrum, memory dysfunction correlated with cortical thinning and increased mean diffusivity (MD) in the AD-prone GM and adjacent WM regions, respectively, and decreased fractional anisotropy (FA) in the WM connecting these brain regions. Regarding the LBCI spectrum, memory dysfunction only correlated with increased MD in the WM adjacent to the anteromedial temporal, insula, and basal frontal cortices. For visuospatial dysfunction, the ADCI spectrum was correlated with cortical thinning in the posterior brain regions, while the LBCI spectrum correlated with decreased FA in the corpus callosum and widespread WM regions. Attention/executive dysfunction correlated with cortical thinning and WM abnormalities in widespread brain regions in both disease spectra; however, ADCI and LBCI correlated more prominently with cortical thinning and decreased FA, respectively." @default.
- W2980937299 created "2019-10-25" @default.
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- W2980937299 date "2019-07-01" @default.
- W2980937299 modified "2023-09-28" @default.
- W2980937299 title "P4-572: NEURAL CORRELATES OF COGNITIVE PERFORMANCE IN ALZHEIMER'S DISEASE AND LEWY BODY DISEASE SPECTRA" @default.
- W2980937299 doi "https://doi.org/10.1016/j.jalz.2019.08.120" @default.
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