FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980938711> ?p ?o ?g. }

• W2980938711 abstract "In the absence of disease-modifying therapies for Alzheimer's disease (AD), there is a critical need to identify potentially modifiable risk factors that may delay the progression of AD. Here, we examined the protective effect of physical activity on subsequent cognitive decline and neurodegeneration in individuals with elevated β-amyloid (Aβ) burden. We examined longitudinal imaging and cognitive data from 182 clinically-normal older adults in the Harvard Aging Brain Study (mean age=73.4±6.2 years). Baseline physical activity was quantified with a pedometer (mean steps per day). Baseline Aβ burden was measured with 11-C Pittsburgh Compound-B positron emission tomography. Cognition was measured annually with the Preclinical Alzheimer Cognitive Composite (PACC; median follow-up=6.0±1.1 years). Neurodegeneration was assessed with longitudinal structural magnetic resonance imaging (2–4 scans per subject, median follow-up=4.5±1.3 years). Physical activity and Aβ were examined as interactive predictors of cognitive decline and gray matter volume loss in separate linear mixed models, adjusting for covariates. Since neurodegeneration has been closely associated with cognitive decline, we also assessed whether gray matter atrophy mediates the association between physical activity and cognitive decline. In models predicting PACC decline and gray matter volume loss, there was a significant interaction of physical activity with Aβ burden, whereby greater physical activity attenuated the negative impact of Aβ burden on cognitive decline (t =3.7; P<0.001; Figure 1) and neurodegeneration (t =3.2; P=0.002; Figure 2). Adjusting for vascular risk, as measured by the Framingham Risk Score, did not alter these associations. In these models, lower vascular risk was independently associated with slower Aβ-related cognitive decline (t =3.6; P<0.001) and neurodegeneration (t =2.5; P=0.01). Follow-up regional analyses suggested that, in individuals with elevated Aβ burden, greater physical activity was associated with slower cortical thinning in medial and lateral temporal, medial parietal regions, and insula (Figure 3). Finally, mediation analyses revealed both significant direct and gray matter volume-mediated effects of physical activity on PACC decline in the setting of elevated Aβ burden." @default.
• W2980938711 created "2019-10-25" @default.
• W2980938711 creator A5001795846 @default.
• W2980938711 creator A5005435770 @default.
• W2980938711 creator A5018159419 @default.
• W2980938711 creator A5031209685 @default.
• W2980938711 creator A5033852918 @default.
• W2980938711 creator A5036040848 @default.
• W2980938711 creator A5038245254 @default.
• W2980938711 creator A5040195970 @default.
• W2980938711 creator A5050572872 @default.
• W2980938711 creator A5055843167 @default.
• W2980938711 creator A5056034076 @default.
• W2980938711 creator A5060579041 @default.
• W2980938711 creator A5061174828 @default.
• W2980938711 creator A5062524530 @default.
• W2980938711 creator A5066159823 @default.
• W2980938711 creator A5074023767 @default.
• W2980938711 creator A5076768887 @default.
• W2980938711 creator A5084960048 @default.
• W2980938711 creator A5088915384 @default.
• W2980938711 creator A5090842068 @default.
• W2980938711 date "2019-07-01" @default.
• W2980938711 modified "2023-10-09" @default.
• W2980938711 title "O3-09-01: PROTECTIVE EFFECT OF PHYSICAL ACTIVITY ON LONGITUDINAL COGNITIVE DECLINE AND NEURODEGENERATION IN CLINICALLY NORMAL OLDER ADULTS WITH ELEVATED β-AMYLOID BURDEN" @default.
• W2980938711 doi "https://doi.org/10.1016/j.jalz.2019.06.4672" @default.
• W2980938711 hasPublicationYear "2019" @default.
• W2980938711 type Work @default.
• W2980938711 sameAs 2980938711 @default.
• W2980938711 citedByCount "0" @default.
• W2980938711 crossrefType "journal-article" @default.
• W2980938711 hasAuthorship W2980938711A5001795846 @default.
• W2980938711 hasAuthorship W2980938711A5005435770 @default.
• W2980938711 hasAuthorship W2980938711A5018159419 @default.
• W2980938711 hasAuthorship W2980938711A5031209685 @default.
• W2980938711 hasAuthorship W2980938711A5033852918 @default.
• W2980938711 hasAuthorship W2980938711A5036040848 @default.
• W2980938711 hasAuthorship W2980938711A5038245254 @default.
• W2980938711 hasAuthorship W2980938711A5040195970 @default.
• W2980938711 hasAuthorship W2980938711A5050572872 @default.
• W2980938711 hasAuthorship W2980938711A5055843167 @default.
• W2980938711 hasAuthorship W2980938711A5056034076 @default.
• W2980938711 hasAuthorship W2980938711A5060579041 @default.
• W2980938711 hasAuthorship W2980938711A5061174828 @default.
• W2980938711 hasAuthorship W2980938711A5062524530 @default.
• W2980938711 hasAuthorship W2980938711A5066159823 @default.
• W2980938711 hasAuthorship W2980938711A5074023767 @default.
• W2980938711 hasAuthorship W2980938711A5076768887 @default.
• W2980938711 hasAuthorship W2980938711A5084960048 @default.
• W2980938711 hasAuthorship W2980938711A5088915384 @default.
• W2980938711 hasAuthorship W2980938711A5090842068 @default.
• W2980938711 hasBestOaLocation W29809387111 @default.
• W2980938711 hasConcept C118552586 @default.
• W2980938711 hasConcept C126322002 @default.
• W2980938711 hasConcept C126838900 @default.
• W2980938711 hasConcept C143409427 @default.
• W2980938711 hasConcept C15744967 @default.
• W2980938711 hasConcept C169900460 @default.
• W2980938711 hasConcept C185711340 @default.
• W2980938711 hasConcept C2776925932 @default.
• W2980938711 hasConcept C2779134260 @default.
• W2980938711 hasConcept C2779483572 @default.
• W2980938711 hasConcept C2781073650 @default.
• W2980938711 hasConcept C2781172350 @default.
• W2980938711 hasConcept C2984863031 @default.
• W2980938711 hasConcept C502032728 @default.
• W2980938711 hasConcept C58693492 @default.
• W2980938711 hasConcept C65835030 @default.
• W2980938711 hasConcept C71924100 @default.
• W2980938711 hasConcept C74909509 @default.
• W2980938711 hasConceptScore W2980938711C118552586 @default.
• W2980938711 hasConceptScore W2980938711C126322002 @default.
• W2980938711 hasConceptScore W2980938711C126838900 @default.
• W2980938711 hasConceptScore W2980938711C143409427 @default.
• W2980938711 hasConceptScore W2980938711C15744967 @default.
• W2980938711 hasConceptScore W2980938711C169900460 @default.
• W2980938711 hasConceptScore W2980938711C185711340 @default.
• W2980938711 hasConceptScore W2980938711C2776925932 @default.
• W2980938711 hasConceptScore W2980938711C2779134260 @default.
• W2980938711 hasConceptScore W2980938711C2779483572 @default.
• W2980938711 hasConceptScore W2980938711C2781073650 @default.
• W2980938711 hasConceptScore W2980938711C2781172350 @default.
• W2980938711 hasConceptScore W2980938711C2984863031 @default.
• W2980938711 hasConceptScore W2980938711C502032728 @default.
• W2980938711 hasConceptScore W2980938711C58693492 @default.
• W2980938711 hasConceptScore W2980938711C65835030 @default.
• W2980938711 hasConceptScore W2980938711C71924100 @default.
• W2980938711 hasConceptScore W2980938711C74909509 @default.
• W2980938711 hasIssue "7S_Part_17" @default.
• W2980938711 hasLocation W29809387111 @default.
• W2980938711 hasOpenAccess W2980938711 @default.
• W2980938711 hasPrimaryLocation W29809387111 @default.
• W2980938711 hasRelatedWork W1540168105 @default.
• W2980938711 hasRelatedWork W1977920679 @default.
• W2980938711 hasRelatedWork W2135547432 @default.
• W2980938711 hasRelatedWork W2766474056 @default.
• W2980938711 hasRelatedWork W2897534978 @default.
• W2980938711 hasRelatedWork W2905731172 @default.
• W2980938711 hasRelatedWork W2980938711 @default.
• W2980938711 hasRelatedWork W4210765326 @default.

• next