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- W2980939228 abstract "Although intermittent hypoxic training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This study was to test if IHT was safe as a novel intervention for treating patients with MCI. Seven MCI patients (age 69±3, 6 women) alternately breathed 10% O2 and room air (each 5 min) for 8 cycles/session, 3 sessions/week for 8 weeks. Before and after the IHT program, mean arterial pressure (MAP), arterial O2 saturation (SaO2), cerebral tissue O2 saturation (ScO2) and middle cerebral artery flow velocity (VMCA) were assessed at rest and during 5-min hypoxic exposure. Cognitive performance tests including mini-mental status exam (MMSE), California verbal learning test-II (CVLT-II), digit span, trail making test-B (TMT-B), and controlled oral word association test (COWAT) were administered pre- and post-IHT. Resting MAP fell from 101±3 to 95±3 mmHg (P<0.05) and resting ScO2 increased from 67.9±1.2 to 70.7±1.6% (P<0.01) after the IHT program, without altering resting VMCA (pre vs post: 46.8±3.0 vs 44.2±1.9 cm/s, P=0.21). During the 5th min of hypoxic challenge, SaO2 similarly fell to 70.3±2.9 and 73.8±1.4% pre- and post-IHT, respectively. The hypoxia-induced VMCA increase doubled from 4.5±2.2 before to 9.2±1.8 cm/s after IHT (P<0.05), yet ScO2 during 5-min hypoxia remained greater post- vs pre-IHT (P<0.05). IHT increased MMSE and digit span scores from 25.7±0.4 to 27.7±0.6 (P=0.038) and from 24.7±1.2 to 26.1±1.3 (P=0.047), respectively, and tended to increase CVLT-II score (pre vs post: 54.6±3.5 vs 61.0±4.6, P=0.102); TMT-B and COWAT were unchanged. Readily tolerated IHT enhances ScO2 and cerebral vasodilation during hypoxia, and improves short-term memory and concentration ability in MCI patients." @default.
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- W2980939228 date "2019-07-01" @default.
- W2980939228 modified "2023-09-27" @default.
- W2980939228 title "P2-003: INTERMITTENT HYPOXIC TRAINING FOR TREATING MILD COGNITIVE IMPAIRMENT" @default.
- W2980939228 doi "https://doi.org/10.1016/j.jalz.2019.06.1225" @default.
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