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- W2980944107 abstract "Focusing on potential biological and pharmaceutical activities of rosmarinic acid (RA), this study was conducted with the aim of improving the long-term stability of RA by one-step fabrication of a novel ternary electrosprayed microparticle system based on poly (lactic-co-glycolic acid) (PLGA) where surfactant molecules served as the compatibilizer modifying interfacial properties of RA and PLGA. Effects of polymer concentration and initial ratio of RA to PLGA in the presence of surfactant molecules on microparticle morphology, release profile, and bioactivities were studied. Particle size and loading efficiency were respectively increased and decreased, by increasing either the initial ratio of RA to PLGA or the polymer concentration. RA release from microparticles followed Fickian or quasi-Fickian diffusion mechanism. The location of drug inside microparticles resulted from surfactant-associated polymer-drug interaction was found as the dominant rate-controlling release mechanism while the microparticle size played a collaborative role. RA-loaded PLGA microparticles exhibited antioxidant and antibacterial activities and released no major harmful substance to human dermal fibroblasts. The evidence suggests that electrosprayed RA-loaded PLGA microparticles can be employed in cosmetic and pharmaceutical products." @default.
- W2980944107 created "2019-10-25" @default.
- W2980944107 creator A5043394091 @default.
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- W2980944107 date "2020-01-01" @default.
- W2980944107 modified "2023-09-25" @default.
- W2980944107 title "Surfactant-assisted incorporation of rosmarinic acid into electrosprayed poly(lactic-co-glycolic acid) microparticles with potential for cosmetic and pharmaceutical applications" @default.
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- W2980944107 doi "https://doi.org/10.1016/j.polymertesting.2019.106180" @default.
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