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- W2980953887 abstract "Recent studies had defined a distinct category of Alzheimer's type neurofibrillary degeneration that occurs in the absence of amyloid pathology. While tau pathology in Alzheimer's disease (AD) develops first in the medial temporal lobe and progresses to neocortical brain regions, tau pathology does not progress beyond the medial temporal lobe in PART. Since tau progresses in a different pattern in PART, there is a need to reassess and improve upon how tau pathology is measured in these amyloid-negative individuals for clinicopathological and genetic studies. Using a large collection of well-defined neuropathologically ascertained subjects with PART derived from multiple centers, we reassessed tau and other degenerative pathologies (e.g., Braak NFT stage, CERAD neuritic plaque burden, Thal phase) and correlated with clinical assessments (i.e., clinical dementia rating [CDR] and mini mental status exam [MMSE]). Patients were categorized as PART-definite (absence of neuritic amyloid plaques; n=63) and PART-probable (sparse neuritic amyloid plaques; n=39). We also performed computer-assisted morphometric assessment of tau burden. Variables associated with the cognitive measures were determined using multivariable logistic regression. Neuropathological and clinical assessments statistically differed for the PART-definite and PART-probable groups. The computer-assisted morphometric assessment of pathological tau was statistically correlated (p<0.05) with tau burden in the medial temporal lobe while Braak staging was not. The factors associated with the PART-definite group and the PART-probable groups were different, suggesting unique clinicopathological profiles. The novel computer-assisted morphometric method might be a more precise way to assess the progression of NFTs in PART." @default.
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- W2980953887 date "2019-07-01" @default.
- W2980953887 modified "2023-09-27" @default.
- W2980953887 title "P4-065: CLINICOPATHOLOGICAL CORRELATIONS IN PRIMARY AGE-RELATED TAUOPATHY" @default.
- W2980953887 doi "https://doi.org/10.1016/j.jalz.2019.06.3725" @default.
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