FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980960135> ?p ?o ?g. }

• W2980960135 endingPage "152310" @default.
• W2980960135 startingPage "152310" @default.
• W2980960135 abstract "Pregabalin (PRG) is highly effective in the treatment of epilepsy, neuropathic pain and anxiety disorders. Despite its potential benefits, PRG administration has been reported to induce or exacerbate heart failure (HF). It has been previously documented that overactivation of the renin angiotensin system (RAS) is involved in HF pathophysiological mechanism. The target of the current study was to examine the possible cardioprotective effect of telmisartan (Tel), an angiotensin II type 1 receptor (AT1R) blocker, compared with that of captopril (Cap), an angiotensin converting enzyme (ACE) inhibitor, in ameliorating PRG-induced HF in rats by assessing morphometric, echocardiographic and histopathological parameters. Furthermore, to investigate the role of RAS blockade by the two drugs in guarding against PRG-induced changes in cardiac angiotensin 1-7 (Ang 1-7) and angiotensin II (Ang II) levels, in addition to myocardial expression of ACE2, ACE, Mas receptor (MasR) and AT1R. Results showed that PRG administration induced morphometric, echocardiographic and histopathological deleterious alterations and significantly elevated cardiac Ang II, ACE and AT1R levels, while reduced Ang 1-7, ACE2 and MasR cardiac levels. Concurrent treatment with either Tel or Cap reversed PRG-induced morphometric, echocardiographic and histopathological abnormalities and revealed prominent protection against PRG-induced HF via downregulation of ACE/Ang II/AT1R and upregulation of ACE2/Ang 1-7/MasR axes. These are the first findings to demonstrate that the potential benefits of Tel and Cap are mediated by counteracting the altered balance between the RAS axes induced by PRG. Hence; Tel and Cap may attenuate PRG-induced HF partially through stimulation of ACE2/Ang 1-7/MasR pathway." @default.
• W2980960135 created "2019-10-25" @default.
• W2980960135 creator A5024087886 @default.
• W2980960135 creator A5052192337 @default.
• W2980960135 creator A5067902494 @default.
• W2980960135 creator A5073244900 @default.
• W2980960135 creator A5083261947 @default.
• W2980960135 date "2019-12-01" @default.
• W2980960135 modified "2023-10-18" @default.
• W2980960135 title "Telmisartan and captopril ameliorate pregabalin-induced heart failure in rats" @default.
• W2980960135 cites W1966980077 @default.
• W2980960135 cites W1969947521 @default.
• W2980960135 cites W1971714718 @default.
• W2980960135 cites W1972855948 @default.
• W2980960135 cites W1995299367 @default.
• W2980960135 cites W1997002994 @default.
• W2980960135 cites W2003077142 @default.
• W2980960135 cites W2018815411 @default.
• W2980960135 cites W2028203874 @default.
• W2980960135 cites W2028521865 @default.
• W2980960135 cites W2032690812 @default.
• W2980960135 cites W2034361879 @default.
• W2980960135 cites W2041065149 @default.
• W2980960135 cites W2045397597 @default.
• W2980960135 cites W2046670706 @default.
• W2980960135 cites W2047089949 @default.
• W2980960135 cites W2047339188 @default.
• W2980960135 cites W2055023418 @default.
• W2980960135 cites W2055523882 @default.
• W2980960135 cites W2055889100 @default.
• W2980960135 cites W2056157464 @default.
• W2980960135 cites W2056344654 @default.
• W2980960135 cites W2069733524 @default.
• W2980960135 cites W2069943217 @default.
• W2980960135 cites W2070375868 @default.
• W2980960135 cites W2071881835 @default.
• W2980960135 cites W2083152534 @default.
• W2980960135 cites W2083529118 @default.
• W2980960135 cites W2084250730 @default.
• W2980960135 cites W2085560662 @default.
• W2980960135 cites W2088802331 @default.
• W2980960135 cites W2093962101 @default.
• W2980960135 cites W2099769151 @default.
• W2980960135 cites W2104876188 @default.
• W2980960135 cites W2110616439 @default.
• W2980960135 cites W2117117656 @default.
• W2980960135 cites W2118638261 @default.
• W2980960135 cites W2122766152 @default.
• W2980960135 cites W2123524472 @default.
• W2980960135 cites W2127410615 @default.
• W2980960135 cites W2129035083 @default.
• W2980960135 cites W2132812047 @default.
• W2980960135 cites W2133466283 @default.
• W2980960135 cites W2141980757 @default.
• W2980960135 cites W2144763581 @default.
• W2980960135 cites W2148029309 @default.
• W2980960135 cites W2158688455 @default.
• W2980960135 cites W2159977024 @default.
• W2980960135 cites W2163875826 @default.
• W2980960135 cites W2164005268 @default.
• W2980960135 cites W2167767922 @default.
• W2980960135 cites W2168907840 @default.
• W2980960135 cites W2280514257 @default.
• W2980960135 cites W2326229853 @default.
• W2980960135 cites W2345230484 @default.
• W2980960135 cites W2474345330 @default.
• W2980960135 cites W2556202551 @default.
• W2980960135 cites W2579200252 @default.
• W2980960135 cites W2596242241 @default.
• W2980960135 cites W2625113972 @default.
• W2980960135 cites W2658072281 @default.
• W2980960135 cites W2753525372 @default.
• W2980960135 cites W2764157735 @default.
• W2980960135 cites W2804091304 @default.
• W2980960135 cites W2806768805 @default.
• W2980960135 cites W2921435588 @default.
• W2980960135 cites W2755619888 @default.
• W2980960135 doi "https://doi.org/10.1016/j.tox.2019.152310" @default.
• W2980960135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31629013" @default.
• W2980960135 hasPublicationYear "2019" @default.
• W2980960135 type Work @default.
• W2980960135 sameAs 2980960135 @default.
• W2980960135 citedByCount "13" @default.
• W2980960135 countsByYear W29809601352020 @default.
• W2980960135 countsByYear W29809601352021 @default.
• W2980960135 countsByYear W29809601352022 @default.
• W2980960135 countsByYear W29809601352023 @default.
• W2980960135 crossrefType "journal-article" @default.
• W2980960135 hasAuthorship W2980960135A5024087886 @default.
• W2980960135 hasAuthorship W2980960135A5052192337 @default.
• W2980960135 hasAuthorship W2980960135A5067902494 @default.
• W2980960135 hasAuthorship W2980960135A5073244900 @default.
• W2980960135 hasAuthorship W2980960135A5083261947 @default.
• W2980960135 hasConcept C104317684 @default.
• W2980960135 hasConcept C123915805 @default.
• W2980960135 hasConcept C126322002 @default.
• W2980960135 hasConcept C127561419 @default.
• W2980960135 hasConcept C134018914 @default.

• next