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- W2980967060 abstract "Beta-amyloid (Aβ) deposition and such white matter (WM) alterations are two pathological hallmarks of Alzheimer's disease dementia (ADD). The alteration of Tau protein also associated with the disease may be related to WM abnormalities (microstructural damage and demyelination). Improved characterization of the microstructural brain changes occurring in the early stages of ADD might allow more timely disease detection. The aim of this study is to verify differences between individual's pre-ADD stage with or without Tau protein alteration, using Diffusion Tensor Imaging (DTI) measures, i.e. axial diffusivity (AD), radial diffusivity (RD) and fractional anisotropy (FA). 26 patients with amnestic Mild Cognitive Impairment (aMCI) underwent: lumbar puncture to analyze Aβ1-42, phosphorylated Tau (p-Tau) and total Tau (t-Tau) levels and MRI in a 3T scanner. All participants had pathophysiological evidence of ADD (low Aβ1-42 concentrations < 540pg/mL) and was considered Tau alteration: p-Tau > 36.7 pg/mL and t-Tau > 76.7 pg/mL. To analyze WM integrity, we used an automated segmentation method – MultiAtlas to extract FA, RD and AD measures. Statistical analyses were performed using SPSS software (version 22). We conducted a paired t-test to evaluate presence of Tau protein alteration (present/absent) and DTI measures. We did not found differences in FA measure between groups of p-Tau alteration. However the group with p-Tau alteration presented altered AD in genu of corpus callosum (GCC) and body of corpus callosum tracts (BCC) (p=0.004 and p=0.021, respectively); and altered RD in BCC tract (p=0.044). We did not find differences between t-Tau alterations regarding FA and RD measures; however we found that the group presented altered t-Tau has more AD in fornix (p=0.028) and GCC (p=0.034) tracts. Tau protein-positive patients presented with more AD and RD abnormalities in regions related to cognitive deficits and the accumulation of senile plaques containing Aβ. Disconnection of these areas through WM abnormalities (e.g. lesions) may be partly responsible for clinical worsening." @default.
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- W2980967060 date "2019-07-01" @default.
- W2980967060 modified "2023-10-07" @default.
- W2980967060 title "P4-150: ALTERATION OF TAU PROTEIN IN INDIVIDUAL'S PRE-ALZHEIMER'S DISEASE STAGE AND ABNORMALITIES IN WHITE MATTER" @default.
- W2980967060 doi "https://doi.org/10.1016/j.jalz.2019.06.3811" @default.
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