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- W2980971995 abstract "Mutational characterisation is described in newly diagnosed (ND) multiple myeloma (MM) but remains largely elusive for relapsed/refractory (RR) patients. Current practice for mutational characterisation is via analysis of DNA from single-site bone marrow (BM) biopsies, which is confounded by the known inter and intra-clonal spatial heterogeneity of the tumour(s). An alternative and more comprehensive approach is through the analysis of circulating cell-free (cf) tumour DNA (ctDNA) derived from the plasma (PL). In this study, MM mutational characterisation was performed on BM MM cell DNA and PL-derived ctDNA from both ND and RR patients to investigate if predominant mutations in the advanced tumour genome can be identified through PL ctDNA analysis." @default.
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- W2980971995 date "2019-10-01" @default.
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- W2980971995 title "DNA-repair gene mutations are prevalent in circulating tumour DNA from advanced multiple myeloma patients" @default.
- W2980971995 doi "https://doi.org/10.1016/j.clml.2019.09.126" @default.
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