FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980974360> ?p ?o ?g. }

• W2980974360 endingPage "e1008232" @default.
• W2980974360 startingPage "e1008232" @default.
• W2980974360 abstract "In nature, most bacteria live in biofilms where they compete with their siblings and other species for space and nutrients. Some bacteria produce antibiotics in biofilms; however, since the diffusion of antibiotics is generally hindered in biofilms by extracellular polymeric substances, i.e., the biofilm matrix, their function remains unclear. The Bacillus subtilis yitPOM operon is a paralog of the sdpABC operon, which produces the secreted peptide toxin SDP. Unlike sdpABC, yitPOM is induced in biofilms by the DegS-DegU two-component regulatory system. High yitPOM expression leads to the production of a secreted toxin called YIT. Expression of yitQ, which lies upstream of yitPOM, confers resistance to the YIT toxin, suggesting that YitQ is an anti-toxin protein for the YIT toxin. The alternative sigma factor SigW also contributes to YIT toxin resistance. In a mutant lacking yitQ and sigW, the YIT toxin specifically inhibits biofilm formation, and the extracellular neutral protease NprB is required for this inhibition. The requirement for NprB is eliminated by Δeps and ΔbslA mutations, either of which impairs production of biofilm matrix polymers. Overexpression of biofilm matrix polymers prevents the action of the SDP toxin but not the YIT toxin. These results indicate that, unlike the SDP toxin and many conventional antibiotics, the YIT toxin can pass through layers of biofilm matrix polymers to attack cells within biofilms with assistance from NprB. When the wild-type strain and the YIT-sensitive mutant were grown together on a solid medium, the wild-type strain formed biofilms that excluded the YIT-sensitive mutant. This observation suggests that the YIT toxin protects B. subtilis biofilms against competitors. Several bacteria are known to produce antibiotics in biofilms. We propose that some bacteria including B. subtilis may have evolved specialized antibiotics that can function within biofilms." @default.
• W2980974360 created "2019-10-25" @default.
• W2980974360 creator A5020961774 @default.
• W2980974360 creator A5080530083 @default.
• W2980974360 date "2019-10-17" @default.
• W2980974360 modified "2023-10-07" @default.
• W2980974360 title "Biofilm-associated toxin and extracellular protease cooperatively suppress competitors in Bacillus subtilis biofilms" @default.
• W2980974360 cites W1514432626 @default.
• W2980974360 cites W1525729912 @default.
• W2980974360 cites W1581944902 @default.
• W2980974360 cites W1660668583 @default.
• W2980974360 cites W1730500298 @default.
• W2980974360 cites W1845220076 @default.
• W2980974360 cites W1881113194 @default.
• W2980974360 cites W1972452577 @default.
• W2980974360 cites W1972868476 @default.
• W2980974360 cites W1996442931 @default.
• W2980974360 cites W1999681667 @default.
• W2980974360 cites W2005036291 @default.
• W2980974360 cites W2015583490 @default.
• W2980974360 cites W2026626836 @default.
• W2980974360 cites W2030148834 @default.
• W2980974360 cites W2040539560 @default.
• W2980974360 cites W2051858003 @default.
• W2980974360 cites W2058406790 @default.
• W2980974360 cites W2060051187 @default.
• W2980974360 cites W2070300719 @default.
• W2980974360 cites W2070399793 @default.
• W2980974360 cites W2070856482 @default.
• W2980974360 cites W2080936059 @default.
• W2980974360 cites W2082059574 @default.
• W2980974360 cites W2082658471 @default.
• W2980974360 cites W2084524312 @default.
• W2980974360 cites W2086603752 @default.
• W2980974360 cites W2087008980 @default.
• W2980974360 cites W2090646249 @default.
• W2980974360 cites W2092740268 @default.
• W2980974360 cites W2098570486 @default.
• W2980974360 cites W2099487698 @default.
• W2980974360 cites W2102344709 @default.
• W2980974360 cites W2102454428 @default.
• W2980974360 cites W2103917250 @default.
• W2980974360 cites W2106616046 @default.
• W2980974360 cites W2108157915 @default.
• W2980974360 cites W2110094056 @default.
• W2980974360 cites W2116364469 @default.
• W2980974360 cites W2120816646 @default.
• W2980974360 cites W2120978086 @default.
• W2980974360 cites W2127535305 @default.
• W2980974360 cites W2128537309 @default.
• W2980974360 cites W2131064330 @default.
• W2980974360 cites W2140777434 @default.
• W2980974360 cites W2141401164 @default.
• W2980974360 cites W2143160816 @default.
• W2980974360 cites W2143768216 @default.
• W2980974360 cites W2144360067 @default.
• W2980974360 cites W2144821695 @default.
• W2980974360 cites W2151062423 @default.
• W2980974360 cites W2152042119 @default.
• W2980974360 cites W2153584471 @default.
• W2980974360 cites W2154289641 @default.
• W2980974360 cites W2155905840 @default.
• W2980974360 cites W2156438853 @default.
• W2980974360 cites W2156495539 @default.
• W2980974360 cites W2168177244 @default.
• W2980974360 cites W2168952228 @default.
• W2980974360 cites W2170907507 @default.
• W2980974360 cites W2277281665 @default.
• W2980974360 cites W2466645477 @default.
• W2980974360 cites W2519777519 @default.
• W2980974360 cites W2604942130 @default.
• W2980974360 cites W2746828072 @default.
• W2980974360 cites W2883562079 @default.
• W2980974360 cites W2909656211 @default.
• W2980974360 cites W2949080149 @default.
• W2980974360 doi "https://doi.org/10.1371/journal.pgen.1008232" @default.
• W2980974360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6818787" @default.
• W2980974360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31622331" @default.
• W2980974360 hasPublicationYear "2019" @default.
• W2980974360 type Work @default.
• W2980974360 sameAs 2980974360 @default.
• W2980974360 citedByCount "22" @default.
• W2980974360 countsByYear W29809743602021 @default.
• W2980974360 countsByYear W29809743602022 @default.
• W2980974360 countsByYear W29809743602023 @default.
• W2980974360 crossrefType "journal-article" @default.
• W2980974360 hasAuthorship W2980974360A5020961774 @default.
• W2980974360 hasAuthorship W2980974360A5080530083 @default.
• W2980974360 hasBestOaLocation W29809743601 @default.
• W2980974360 hasConcept C104317684 @default.
• W2980974360 hasConcept C143065580 @default.
• W2980974360 hasConcept C181199279 @default.
• W2980974360 hasConcept C203075996 @default.
• W2980974360 hasConcept C2776714187 @default.
• W2980974360 hasConcept C2777272437 @default.
• W2980974360 hasConcept C2777367657 @default.
• W2980974360 hasConcept C523546767 @default.
• W2980974360 hasConcept C54355233 @default.

• next