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- W2980977924 abstract "Dynamic biointerfaces with reversible surface bioactivities enable dynamic modulation of cell–material interactions, thus attracting great attention in biomedical science. Herein, we demonstrated a paradigm shift of dynamic biointerfaces from macroscopical substrates to micron-sized particles by reversible engineering of a phenylboronic acid (PBA)-functionalized magnetic microbead with mussel-inspired cancer cell-targeting peptide. Due to reversible catechol–boronate interactions between the peptides and microbeads, the micron-sized dynamic biointerface exhibited sugar-responsive cancer-targeting activity, showing the potential as a microplatform for magnetic and noninvasive isolation of cancer cells through natural biofeedback mechanism (e.g., human glycemic volatility). Our results demonstrated that the dynamic magnetic platform was capable of selective cancer cell capture (∼85%) and sugar-triggered release of them (>93%) in cell culture medium with high efficiency. More importantly, by using this platform, a decent number of target cells (∼23 on average) could be magnetically isolated and identified from artificial CTC blood samples (1 mL) spiked with 100 cancer cells. In view of the biomimetic nature, high capture efficiency, excellent selectivity, and superiority in cell separation and purification processes, the dynamic magnetic microplatform reported here would be a promising and general tool for rare cell detection and separation and cell-based disease diagnosis." @default.
- W2980977924 created "2019-10-25" @default.
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- W2980977924 date "2019-10-14" @default.
- W2980977924 modified "2023-10-16" @default.
- W2980977924 title "A Magnetic Dynamic Microbiointerface with Biofeedback Mechanism for Cancer Cell Capture and Release" @default.
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- W2980977924 doi "https://doi.org/10.1021/acsami.9b13140" @default.
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