Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980978508> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2980978508 abstract "Small vessel disease (SVD) affects cognitive function in not only vascular cognitive impairment but also neurodegenerative dementia. Hypertension is one of the most important determinants of SVD. A significant number of patients develop SVD regardless of hypertension. However, it is not well known about the distribution, severity, and clinical impact of SVD in patients without hypertension. This study aimed to investigate the characteristics of non-hypertensive SVD. This is a single-center prospective observational study with nested case-control design. Using a prospective stroke registry, non-hypertension was defined as meeting all the following criteria: i) no history of hypertension prior to stroke, ii) no antihypertensive medication before admission, at discharge, and during outpatient care until one year from stroke onset, iii) mean systolic blood pressure <140 mmHg and diastolic blood pressure <90 mmHg from 4 days after hospitalization to discharge, and iv) no left ventricular hypertrophy in electrocardiography. Hypertension was defined as the case in which an antihypertensive drug was prescribed in a past medical history or was administered at discharge. The hypertensive controls were matched with non-hypertensive cases using age and sex as matching variables (1:1 exact match). SVD was defined according to STRIVE criteria. SVD lesions were registered on the Montreal Neurological Institute templates, and lesion frequency map was reconstructed using in-house MATLAB code. Characteristic patterns of SVD distribution explored by comparisons between cases and controls. A total of 704 subjects were included, and mean age was 68.9±10.7 years. In the hypertensive group, diabetes, hyperlipidemia, atrial fibrillation, coronary artery disease, and antithrombotic agents use was significantly higher than the non-hypertensive group. In the non-hypertensive group, white matter hyperintensities lesion map revealed that the anterior temporal and inferior frontal areas were more frequently involved, and cerebral microbleeds were more frequently observed in the occipital cortex. In the case of lacunar infarction, the non-hypertensive group had fewer lesions in brainstem. We will investigate the interrelationships between these image factors and cognitive functions." @default.
- W2980978508 created "2019-10-25" @default.
- W2980978508 creator A5027349989 @default.
- W2980978508 creator A5030337320 @default.
- W2980978508 creator A5068019940 @default.
- W2980978508 creator A5091036340 @default.
- W2980978508 date "2019-07-01" @default.
- W2980978508 modified "2023-10-16" @default.
- W2980978508 title "P3-403: CLINICAL AND IMAGING CHARACTERISTICS OF NONHYPERTENSIVE CEREBRAL SMALL VESSEL DISEASE" @default.
- W2980978508 doi "https://doi.org/10.1016/j.jalz.2019.06.3437" @default.
- W2980978508 hasPublicationYear "2019" @default.
- W2980978508 type Work @default.
- W2980978508 sameAs 2980978508 @default.
- W2980978508 citedByCount "0" @default.
- W2980978508 crossrefType "journal-article" @default.
- W2980978508 hasAuthorship W2980978508A5027349989 @default.
- W2980978508 hasAuthorship W2980978508A5030337320 @default.
- W2980978508 hasAuthorship W2980978508A5068019940 @default.
- W2980978508 hasAuthorship W2980978508A5091036340 @default.
- W2980978508 hasBestOaLocation W29809785081 @default.
- W2980978508 hasConcept C126322002 @default.
- W2980978508 hasConcept C127413603 @default.
- W2980978508 hasConcept C134018914 @default.
- W2980978508 hasConcept C164705383 @default.
- W2980978508 hasConcept C188816634 @default.
- W2980978508 hasConcept C2776002628 @default.
- W2980978508 hasConcept C2779134260 @default.
- W2980978508 hasConcept C2779161974 @default.
- W2980978508 hasConcept C2779483572 @default.
- W2980978508 hasConcept C2780645631 @default.
- W2980978508 hasConcept C3020110884 @default.
- W2980978508 hasConcept C555293320 @default.
- W2980978508 hasConcept C71924100 @default.
- W2980978508 hasConcept C78519656 @default.
- W2980978508 hasConcept C84393581 @default.
- W2980978508 hasConceptScore W2980978508C126322002 @default.
- W2980978508 hasConceptScore W2980978508C127413603 @default.
- W2980978508 hasConceptScore W2980978508C134018914 @default.
- W2980978508 hasConceptScore W2980978508C164705383 @default.
- W2980978508 hasConceptScore W2980978508C188816634 @default.
- W2980978508 hasConceptScore W2980978508C2776002628 @default.
- W2980978508 hasConceptScore W2980978508C2779134260 @default.
- W2980978508 hasConceptScore W2980978508C2779161974 @default.
- W2980978508 hasConceptScore W2980978508C2779483572 @default.
- W2980978508 hasConceptScore W2980978508C2780645631 @default.
- W2980978508 hasConceptScore W2980978508C3020110884 @default.
- W2980978508 hasConceptScore W2980978508C555293320 @default.
- W2980978508 hasConceptScore W2980978508C71924100 @default.
- W2980978508 hasConceptScore W2980978508C78519656 @default.
- W2980978508 hasConceptScore W2980978508C84393581 @default.
- W2980978508 hasIssue "7S_Part_21" @default.
- W2980978508 hasLocation W29809785081 @default.
- W2980978508 hasOpenAccess W2980978508 @default.
- W2980978508 hasPrimaryLocation W29809785081 @default.
- W2980978508 hasRelatedWork W1967841144 @default.
- W2980978508 hasRelatedWork W2002034594 @default.
- W2980978508 hasRelatedWork W2017711500 @default.
- W2980978508 hasRelatedWork W2018480046 @default.
- W2980978508 hasRelatedWork W2064495796 @default.
- W2980978508 hasRelatedWork W2319489406 @default.
- W2980978508 hasRelatedWork W2333279585 @default.
- W2980978508 hasRelatedWork W2603808924 @default.
- W2980978508 hasRelatedWork W2763816051 @default.
- W2980978508 hasRelatedWork W2889073610 @default.
- W2980978508 hasVolume "15" @default.
- W2980978508 isParatext "false" @default.
- W2980978508 isRetracted "false" @default.
- W2980978508 magId "2980978508" @default.
- W2980978508 workType "article" @default.