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- W2980992034 abstract "Scope The effects of an avocado‐derived fatty acid oxidation (FAO) inhibitor, avocatin B (AvoB), on glucose and lipid metabolism in models of diet‐induced obesity (DIO) and in vitro models of lipotoxicity are evaluated. The safety of its oral consumption in humans is also determined. Methods and results Mice are given high‐fat diets (HFD) for 8 weeks. Thereafter, AvoB or vehicle is administered orally twice weekly for 5 weeks. AvoB inhibits FAO which led to improved glucose tolerance, glucose utilization, and insulin sensitivity. AvoB's effects on metabolism under lipotoxic conditions are evaluated in vitro in pancreatic β‐islet cells and C2C12 myotubes. AvoB inhibits FAO and increases glucose oxidation, resulting in lowering of mitochondrial reactive oxygen species that improves insulin responsiveness in C2C12 myotubes and insulin secretion in INS‐1 (832/13) cells, respectively. A randomized, double‐blind, placebo‐controlled clinical trial in healthy human participants is conducted to assess the safety of AvoB consumption (50 mg or 200 mg per day for 60 days). AvoB is well‐tolerated and not associated with any dose‐limiting toxicity. Conclusion Therapeutic agents that are safe and effectively inhibit FAO and improve DIO‐associated pathologies are currently not available. AvoB's mechanism of action and favorable safety profile highlight its nutritional and clinical importance." @default.
- W2980992034 created "2019-10-25" @default.
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- W2980992034 date "2019-10-29" @default.
- W2980992034 modified "2023-10-02" @default.
- W2980992034 title "Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity" @default.
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- W2980992034 cites W1839791560 @default.
- W2980992034 cites W1942855627 @default.
- W2980992034 cites W1963756943 @default.
- W2980992034 cites W1964403842 @default.
- W2980992034 cites W1972641450 @default.
- W2980992034 cites W1977726249 @default.
- W2980992034 cites W1978495288 @default.
- W2980992034 cites W1989038174 @default.
- W2980992034 cites W1991334358 @default.
- W2980992034 cites W2002923743 @default.
- W2980992034 cites W2004057644 @default.
- W2980992034 cites W2005165301 @default.
- W2980992034 cites W2012740748 @default.
- W2980992034 cites W2012898950 @default.
- W2980992034 cites W2014671368 @default.
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- W2980992034 cites W2021591873 @default.
- W2980992034 cites W2023597944 @default.
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- W2980992034 cites W2030643479 @default.
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- W2980992034 cites W2049501357 @default.
- W2980992034 cites W2059842910 @default.
- W2980992034 cites W2065034018 @default.
- W2980992034 cites W2068527308 @default.
- W2980992034 cites W2073168934 @default.
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- W2980992034 doi "https://doi.org/10.1002/mnfr.201900688" @default.
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