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- W2981007862 abstract "Neurofilament Light (NfL) is a protein related to axonal damage. CSF NfL is a useful biomarker of axonal loss in Alzheimer's. Elevated levels have been linked to hippocampal atrophy in cognitively normal (NC), white matter damage in MCI and disease progression in AD. NfL has been related to small vessel disease and greater functional decline in patients with greater vascular burden. Poorer performance on neurocognitive testing by CN elderly with higher NfL has been shown. Reliable assessment of NfL in blood has enhanced the utility of NfL as a biomarker. The current study investigates the relationship between diagnosis, cognition and levels of NfL in older Mexican Americans, an understudied population with high levels of vascular risk. 544 participants from a study of cognitive aging in Mexican Americans had blood drawn, completed neuropsychological tests and were consensus diagnosed into (NC), MCI or AD using standard criteria. Plasma NfL was measured using Simoa. NfL was log transformed and group comparisons used ANOVA co-varying age and gender. NfL was higher for MCI and AD compared to NC. The impaired groups did not differ. Poorer performance on MMSE and CDR were related to higher NfL. Poorer performance on measures of executive functions (Digit Span, Trails B, EXIT and CLOX 2) was related to higher NfL. Analysis of NCs revealed lower scores on these measures for those with higher NfL. No memory measures were related to NfL levels. Blood based NfL may be a useful biomarker of early change in executive functioning." @default.
- W2981007862 created "2019-10-25" @default.
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- W2981007862 date "2019-07-01" @default.
- W2981007862 modified "2023-09-27" @default.
- W2981007862 title "F5‐01‐03: NEUROFILAMENT LIGHT IN A MEXICAN AMERICAN COHORT" @default.
- W2981007862 doi "https://doi.org/10.1016/j.jalz.2019.06.4825" @default.
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