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- W2981027689 abstract "Over 5 million people are estimated to have Alzheimer's disease (AD) in the United States; this number is expected to triple by 2050. Epidemiological studies indicate that modifiable risk factors characterized by elevated peripheral inflammation such as hypertension and metabolic syndrome are linked to development of neurodegenerative disease, including AD, and controlling blood pressure (BP) protects against AD. Importantly, African Americans (AA) are disproportionately affected by both vascular risk factors and AD than whites. Using multiplexed immunoassays, deep-immunophenotyping by flow cytometry, and cognitive tests, here we tested the hypothesis that cognition negatively correlates with inflammation in a cohort of middle- aged (45-65 yrs), cognitively normal individuals at high risk for AD based on parental history and an overrepresentation of the ApoE4 allele. AA individuals had higher plasma and CSF CRP and plasma IL-6, and lower plasma IL-8 and CSF NGAL than whites. We regressed cognitive scores on plasma and CSF inflammatory factors after adjusting for appropriate confounders (age, sex, education, and ApoE4). MOCA score, which assesses global cognition, negatively associated with plasma NGAL and IL-10, and CSF IL-10, Buschke score, which assesses verbal memory, negatively associated with plasma IL-8, TNF and NGAL, and positively associated with CSF IFNγ. When controlling only for APOE4, verbal memory was positively associated with plasma NGAL and CSF IL-6 and negatively associated with plasma TNF and CSF IL-10 and IL-8. Executive function, as measured by TrailsB score positively associated with CSF IL-8 and TNF protein; when controlling only for APOE4, TrailsB score positively associated with CSF IL-8. Language, as measured by MINT score was positively associated with plasma TNF. Experiments are ongoing to immunophenotype CSF and blood via flow cytometry. This investigation will aid in understanding the relationship and role of central and peripheral inflammation on cognition in individuals at high risk for AD." @default.
- W2981027689 created "2019-10-25" @default.
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- W2981027689 date "2019-07-01" @default.
- W2981027689 modified "2023-09-26" @default.
- W2981027689 title "P3-264: PERIPHERAL AND CENTRAL INFLAMMATION DIFFER BY RACE AND ASSOCIATE WITH COGNITIVE PERFORMANCE IN A POPULATION AT RISK FOR ALZHEIMER'S DISEASE" @default.
- W2981027689 doi "https://doi.org/10.1016/j.jalz.2019.06.3295" @default.
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