FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981034744> ?p ?o ?g. }

• W2981034744 endingPage "144136" @default.
• W2981034744 startingPage "144136" @default.
• W2981034744 abstract "Chronic systolic heart failure (CSHF) was a complex syndrome. Recently, vagus nerve stimulation (VNS), a novel treatment method, has emerged for the treatment of CSHF. therefore the aim of this study was to explore the possible mechanism of VNS treatment alleviating CSHF in rats. Firstly, we found after VNS treatment for 72 h, the level of B-type natriuretic peptide in VNS group was lower than that in CSHF group. In addition, VNS treatment induced the elevated left ventricular ejection fraction level, reduced left ventricular end diastolic volume and left ventricular end systolic volume level in VNS group, suggesting a mitigation of CSHF by VNS. Then we found the level of miR-183-3p in CSHF group was much lower than that in VNS group by High-throughput sequencing. The further results indicated that Bcl-2 interacting protein 3 like (BNIP3L) was identified as the target gene of miR-183-3p, and the expression of BNIP3L was notably reduced in rats of VNS group compared with CSHF group. Moreover, the down-regulated expression of miR-183-3p increased BNIP3L-mediated autophagy in rats of CSHF group compared with VNS group. Further mechanism findings demonstrated that up-regulation of miR-183-3p reduced the expression of BNIP3L, while down-regulation of miR-183-3p facilitated the expression of BNIP3L in H9c2 cells. miR-183-3p could also regulate autophagy by targeting BNIP3L in vitro, which was manifested by overexpression of miR-183-3p to inhibit BNIP3L-mediated autophagy. Our data demonstrated that VNS treatment benefited CSHF via the up-regulation of miRNA-183-3p, which reduced the BNIP3L-mediated autophagy, providing a new therapeutic direction for CSHF." @default.
• W2981034744 created "2019-10-25" @default.
• W2981034744 creator A5016423407 @default.
• W2981034744 creator A5023806511 @default.
• W2981034744 creator A5028933575 @default.
• W2981034744 creator A5038120463 @default.
• W2981034744 creator A5061537073 @default.
• W2981034744 creator A5063917352 @default.
• W2981034744 creator A5081255313 @default.
• W2981034744 creator A5087931233 @default.
• W2981034744 date "2020-02-01" @default.
• W2981034744 modified "2023-10-17" @default.
• W2981034744 title "MicroRNA-183-3p up-regulated by vagus nerve stimulation mitigates chronic systolic heart failure via the reduction of BNIP3L-mediated autophagy" @default.
• W2981034744 cites W1940802192 @default.
• W2981034744 cites W1969849548 @default.
• W2981034744 cites W1985995228 @default.
• W2981034744 cites W1987034100 @default.
• W2981034744 cites W1987115342 @default.
• W2981034744 cites W1991105254 @default.
• W2981034744 cites W2012417896 @default.
• W2981034744 cites W2023712669 @default.
• W2981034744 cites W2028807366 @default.
• W2981034744 cites W2056652793 @default.
• W2981034744 cites W2059110515 @default.
• W2981034744 cites W2059310361 @default.
• W2981034744 cites W2063470850 @default.
• W2981034744 cites W2064967819 @default.
• W2981034744 cites W2067932198 @default.
• W2981034744 cites W2076769172 @default.
• W2981034744 cites W2076901481 @default.
• W2981034744 cites W2078940387 @default.
• W2981034744 cites W2086557228 @default.
• W2981034744 cites W2092101939 @default.
• W2981034744 cites W2103230459 @default.
• W2981034744 cites W2111009165 @default.
• W2981034744 cites W2111559564 @default.
• W2981034744 cites W2113863610 @default.
• W2981034744 cites W2119683726 @default.
• W2981034744 cites W2128694891 @default.
• W2981034744 cites W2136856053 @default.
• W2981034744 cites W2145168941 @default.
• W2981034744 cites W2148340793 @default.
• W2981034744 cites W2153672070 @default.
• W2981034744 cites W2157096314 @default.
• W2981034744 cites W2158535498 @default.
• W2981034744 cites W2160330769 @default.
• W2981034744 cites W2171317360 @default.
• W2981034744 cites W2346660967 @default.
• W2981034744 cites W2398053649 @default.
• W2981034744 cites W2613487802 @default.
• W2981034744 cites W2615731813 @default.
• W2981034744 cites W2619835642 @default.
• W2981034744 cites W2624274346 @default.
• W2981034744 cites W2746494244 @default.
• W2981034744 cites W2806995606 @default.
• W2981034744 cites W2886526876 @default.
• W2981034744 cites W2893453593 @default.
• W2981034744 cites W80308734 @default.
• W2981034744 doi "https://doi.org/10.1016/j.gene.2019.144136" @default.
• W2981034744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31629817" @default.
• W2981034744 hasPublicationYear "2020" @default.
• W2981034744 type Work @default.
• W2981034744 sameAs 2981034744 @default.
• W2981034744 citedByCount "6" @default.
• W2981034744 countsByYear W29810347442020 @default.
• W2981034744 countsByYear W29810347442021 @default.
• W2981034744 countsByYear W29810347442022 @default.
• W2981034744 crossrefType "journal-article" @default.
• W2981034744 hasAuthorship W2981034744A5016423407 @default.
• W2981034744 hasAuthorship W2981034744A5023806511 @default.
• W2981034744 hasAuthorship W2981034744A5028933575 @default.
• W2981034744 hasAuthorship W2981034744A5038120463 @default.
• W2981034744 hasAuthorship W2981034744A5061537073 @default.
• W2981034744 hasAuthorship W2981034744A5063917352 @default.
• W2981034744 hasAuthorship W2981034744A5081255313 @default.
• W2981034744 hasAuthorship W2981034744A5087931233 @default.
• W2981034744 hasConcept C104317684 @default.
• W2981034744 hasConcept C126322002 @default.
• W2981034744 hasConcept C134018914 @default.
• W2981034744 hasConcept C145059251 @default.
• W2981034744 hasConcept C190283241 @default.
• W2981034744 hasConcept C203522944 @default.
• W2981034744 hasConcept C24998067 @default.
• W2981034744 hasConcept C2778198053 @default.
• W2981034744 hasConcept C2780087125 @default.
• W2981034744 hasConcept C2781404750 @default.
• W2981034744 hasConcept C502942594 @default.
• W2981034744 hasConcept C55493867 @default.
• W2981034744 hasConcept C71924100 @default.
• W2981034744 hasConcept C78085059 @default.
• W2981034744 hasConcept C86803240 @default.
• W2981034744 hasConceptScore W2981034744C104317684 @default.
• W2981034744 hasConceptScore W2981034744C126322002 @default.
• W2981034744 hasConceptScore W2981034744C134018914 @default.
• W2981034744 hasConceptScore W2981034744C145059251 @default.
• W2981034744 hasConceptScore W2981034744C190283241 @default.
• W2981034744 hasConceptScore W2981034744C203522944 @default.
• W2981034744 hasConceptScore W2981034744C24998067 @default.

• next