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• W2981065718 abstract "The Aberdeen Children of the Nineteen Fifties (ACONF) is a well-characterised cohort of healthy, community-dwelling individuals, born in Aberdeen, Scotland (UK) between 1950 and 1956. This rich source of data allows us to investigate early- and mid-life risk factors for poor health in later life. Recently, subgroup of this cohort underwent brain magnetic resonance imaging (MRI), as well as health and neuropsychological assessments. Here, we aimed to utilise these life-course data to identify risk-factors for increased brain white matter hyperintensity (WMH) burden: a common MRI finding in older adults, associated with cognitive decline, dementia, stroke and death. We calculated the relative risk (RR) of certain factors on increased global WMH burden in 277 cognitively healthy ACONF participants (mean age = 62.3). Global WMH burden was measured as total WMH volume (ml) using an automated WMH segmentation algorithm. We investigated potential risk factors within the domains of demographics, early-life, medical history, socioeconomic circumstance, late-life objective health, and late-life cognition. We identified elevated risk factors for increased global WMH burden among each domain mentioned above. The most significant risk factors for increased WMH burden in this cohort included medical histories of stroke (RR = 2.642, 95% CI = 1.59 – 4.39), heart disease (RR = 1.864, 95% CI = 1.098 – 3.165), diabetes (RR = 1.903, 95% CI = 1.194 – 3.032), and high cholesterol (RR = 1.566, 95% CI = 1.077 – 2.277). Notable early- and mid-life risk factors approaching significance included birth weight of less than 5.5lbs (RR = 1.697, 95% CI = .913 – 3.153) and working in lower-income occupations (RR = 1.049, 95% CI = .715 – 1.538). We were able to confirm age and cardiometabolic risk factors for increased WMH burden in a relatively young cohort of older adults, and add contributions of emerging early and mid-life risk factors. Many of these cardiometabolic risk factors have their origins in early life and are greatest in those with the least resilience. Future work will involve developing a robust model of risk- and protective determinants of WMH burden." @default.
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• W2981065718 date "2019-07-01" @default.
• W2981065718 modified "2023-09-26" @default.
• W2981065718 title "P2-410: A RISK FACTOR PROFILE OF INCREASED WHITE MATTER HYPERINTENSITY BURDEN IN THE ABERDEEN CHILDREN OF THE NINETEEN FIFTIES COHORT" @default.
• W2981065718 doi "https://doi.org/10.1016/j.jalz.2019.06.2817" @default.
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