FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981075334> ?p ?o ?g. }

• W2981075334 endingPage "240" @default.
• W2981075334 startingPage "240" @default.
• W2981075334 abstract "Stroke is one of the leading causes of death and long-term disability worldwide. Gross saponins of Tribulus terrestris fruit (GSTTF) has been used for neuroprotective therapy on convalescents of ischemic stroke. But the related therapeutic mechanisms have not yet been well investigated. This study aimed to investigate the protective effects of GSTTF on ischemic stroke using metabolomics coupled with network pharmacology analysis. The rat urine sample was collected and profiled by an LC-MS-based metabolomics approach. The pathway analysis was performed based on the highlighted biomarkers, then the network pharmacology approach was applied to screen the potential therapeutic targets of GSTTF. Metabolomics analysis showed that a series of metabolic perturbations occurred in the middle cerebral artery occlusion (MCAO) group compared with the sham group. Gross saponins of Tribulus terrestris fruit can change the MCAO-induced urine metabolic deviations in a reverse manner via regulating multiple metabolic pathways. Two proteins, inducible nitric oxide synthase (NOS2) and glycogen synthase kinase-3 beta (GSK3B), were highlighted by the network pharmacology analysis, which may be the potential therapeutic targets for the GSTTF against ischemic stroke. This study provides an overview of the mechanism of MCAO-induced ischemic stroke and investigates the efficacy of GSTTF in the treatment of ischemic stroke. Further study is needed to reveal its underlying mechanisms more clearly." @default.
• W2981075334 created "2019-10-25" @default.
• W2981075334 creator A5000984914 @default.
• W2981075334 creator A5001535157 @default.
• W2981075334 creator A5001937247 @default.
• W2981075334 creator A5003639991 @default.
• W2981075334 creator A5018867351 @default.
• W2981075334 creator A5028306431 @default.
• W2981075334 creator A5047119168 @default.
• W2981075334 creator A5076298806 @default.
• W2981075334 date "2019-10-21" @default.
• W2981075334 modified "2023-09-26" @default.
• W2981075334 title "Investigating the Protective Effect of Gross Saponins of Tribulus terrestris Fruit against Ischemic Stroke in Rat Using Metabolomics and Network Pharmacology" @default.
• W2981075334 cites W107502543 @default.
• W2981075334 cites W1893551673 @default.
• W2981075334 cites W1968430975 @default.
• W2981075334 cites W1973587217 @default.
• W2981075334 cites W1975454216 @default.
• W2981075334 cites W1977823625 @default.
• W2981075334 cites W1982185581 @default.
• W2981075334 cites W1984151889 @default.
• W2981075334 cites W2002169255 @default.
• W2981075334 cites W2042562580 @default.
• W2981075334 cites W2042952308 @default.
• W2981075334 cites W2047384164 @default.
• W2981075334 cites W2053860443 @default.
• W2981075334 cites W2064026571 @default.
• W2981075334 cites W2076610425 @default.
• W2981075334 cites W2087080095 @default.
• W2981075334 cites W2094836461 @default.
• W2981075334 cites W2096029390 @default.
• W2981075334 cites W2107425720 @default.
• W2981075334 cites W2112505121 @default.
• W2981075334 cites W2121158877 @default.
• W2981075334 cites W2123551980 @default.
• W2981075334 cites W2124679671 @default.
• W2981075334 cites W2135634299 @default.
• W2981075334 cites W2139621750 @default.
• W2981075334 cites W2147669325 @default.
• W2981075334 cites W2155158051 @default.
• W2981075334 cites W2159675211 @default.
• W2981075334 cites W2165681080 @default.
• W2981075334 cites W2169079203 @default.
• W2981075334 cites W2265188196 @default.
• W2981075334 cites W2287772836 @default.
• W2981075334 cites W2339990886 @default.
• W2981075334 cites W2463782122 @default.
• W2981075334 cites W2575711245 @default.
• W2981075334 cites W2582679467 @default.
• W2981075334 cites W2605800653 @default.
• W2981075334 cites W2624683722 @default.
• W2981075334 cites W2786394271 @default.
• W2981075334 cites W2807586373 @default.
• W2981075334 cites W2886108104 @default.
• W2981075334 cites W2911593062 @default.
• W2981075334 cites W2914783967 @default.
• W2981075334 cites W2917507818 @default.
• W2981075334 cites W978308701 @default.
• W2981075334 doi "https://doi.org/10.3390/metabo9100240" @default.
• W2981075334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6835270" @default.
• W2981075334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31640179" @default.
• W2981075334 hasPublicationYear "2019" @default.
• W2981075334 type Work @default.
• W2981075334 sameAs 2981075334 @default.
• W2981075334 citedByCount "17" @default.
• W2981075334 countsByYear W29810753342020 @default.
• W2981075334 countsByYear W29810753342021 @default.
• W2981075334 countsByYear W29810753342022 @default.
• W2981075334 countsByYear W29810753342023 @default.
• W2981075334 crossrefType "journal-article" @default.
• W2981075334 hasAuthorship W2981075334A5000984914 @default.
• W2981075334 hasAuthorship W2981075334A5001535157 @default.
• W2981075334 hasAuthorship W2981075334A5001937247 @default.
• W2981075334 hasAuthorship W2981075334A5003639991 @default.
• W2981075334 hasAuthorship W2981075334A5018867351 @default.
• W2981075334 hasAuthorship W2981075334A5028306431 @default.
• W2981075334 hasAuthorship W2981075334A5047119168 @default.
• W2981075334 hasAuthorship W2981075334A5076298806 @default.
• W2981075334 hasBestOaLocation W29810753341 @default.
• W2981075334 hasConcept C104629339 @default.
• W2981075334 hasConcept C126322002 @default.
• W2981075334 hasConcept C127413603 @default.
• W2981075334 hasConcept C142724271 @default.
• W2981075334 hasConcept C182996813 @default.
• W2981075334 hasConcept C188947578 @default.
• W2981075334 hasConcept C204787440 @default.
• W2981075334 hasConcept C21565614 @default.
• W2981075334 hasConcept C25498285 @default.
• W2981075334 hasConcept C2780645631 @default.
• W2981075334 hasConcept C2781232198 @default.
• W2981075334 hasConcept C3020199598 @default.
• W2981075334 hasConcept C541997718 @default.
• W2981075334 hasConcept C55493867 @default.
• W2981075334 hasConcept C556039675 @default.
• W2981075334 hasConcept C60644358 @default.
• W2981075334 hasConcept C62478195 @default.
• W2981075334 hasConcept C71924100 @default.
• W2981075334 hasConcept C78519656 @default.

• next