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- W2981089838 abstract "Although type 2 diabetes mellitus (DM) is a risk factor for the development of dementia, underlying brain pathologies and mechanisms vary. We classified patients with clinically diagnosed Alzheimer disease (AD) associated with DM into subgroups based on amyloid and tau accumulation patterns on positron emission tomography (PET) and examined the differences in clinical features and brain imaging findings between subgroups. Sixty-two patients with probable or possible AD associated with DM were classified using PiB (amyloid, A) and PBB3 (tau, T) PET studies. Qualitative image analysis was performed by a trained nuclear medicine physician blinded to subjects’ clinical data. Patients were classified into a A+/T+ group (n=33, AD pathology), a A-/T+ group (n=19, tauopathy), and a A-/T- group (n=10, non-amyloid/non-tau neuronal damage). The A-/T+ group showed less-well controlled glycemia, long duration of diabetes, glucose variability, high frequency of insulin therapy and hypoglycemia, impaired executive and attention functions, slow progression of cognitive decline, low frequency of ApoE4 carrier, less severe medial temporal lobe atrophy, and low frequency of posterior cerebral hypoperfusion. This subgroup differs from the A+/T+ (AD pathology) group, in terms of clinical and radiological features, referred to as diabetes-related dementia. There are underlying neuropathology groups different from AD among patients with clinically diagnosed AD with DM. A dementia subgroup suggestive of tauopathy is strongly associated with DM-related metabolic abnormalities. This study highlights the identification of a novel dementia subgroup (diabetes-related dementia) for considering an appropriate therapy and care in clinical practice." @default.
- W2981089838 created "2019-10-25" @default.
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- W2981089838 date "2019-07-01" @default.
- W2981089838 modified "2023-10-16" @default.
- W2981089838 title "P1-345: CLASSIFICATION OF CLINICALLY DIAGNOSED ALZHEIMER DISEASE ASSOCIATED WITH DIABETES BASED ON AMYLOID AND TAU PET" @default.
- W2981089838 doi "https://doi.org/10.1016/j.jalz.2019.06.900" @default.
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