Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981102012> ?p ?o ?g. }
- W2981102012 endingPage "992" @default.
- W2981102012 startingPage "976" @default.
- W2981102012 abstract "Epidemiological studies report associations between air pollution (AP) exposures and several neurodevelopmental disorders including autism, attention deficit disorder, and cognitive delays. Our studies in mice of postnatal (human third trimester brain equivalent) exposures to concentrated ambient ultrafine particles (CAPs) provide biological plausibility for these associations, producing numerous neuropathological and behavioral features of these disorders, including male-biased vulnerability. These findings raise questions about the specific components of AP that underlie its neurotoxicity, which our studies suggest could involve trace elements as candidate neurotoxicants. X-ray fluorescence analyses of CAP chamber filters confirm contamination of AP exposures by multiple elements, including iron (Fe) and sulfur (S). Correspondingly, laser ablation inductively coupled plasma mass spectrometry of brains of male mice indicates marked postexposure elevations of Fe and S and other elements. Elevations of brain Fe and S in particular are consistent with potential ferroptotic, oxidative stress, and altered antioxidant capacity-based mechanisms of CAPs-induced neurotoxicity, supported by observations of increased serum oxidized glutathione and increased neuronal cell death in nucleus accumbens with no corresponding significant increase in caspase-3, in male brains following postnatal CAP exposures. Understanding the role of trace element contaminants of particulate matter AP as a source of neurotoxicity is critical for public health protection." @default.
- W2981102012 created "2019-10-25" @default.
- W2981102012 creator A5001059833 @default.
- W2981102012 creator A5016062922 @default.
- W2981102012 creator A5016697206 @default.
- W2981102012 creator A5041971539 @default.
- W2981102012 creator A5046865885 @default.
- W2981102012 creator A5047603122 @default.
- W2981102012 creator A5060407790 @default.
- W2981102012 creator A5077341365 @default.
- W2981102012 date "2019-10-14" @default.
- W2981102012 modified "2023-10-06" @default.
- W2981102012 title "The Impact of Inhaled Ambient Ultrafine Particulate Matter on Developing Brain: Potential Importance of Elemental Contaminants" @default.
- W2981102012 cites W1486947477 @default.
- W2981102012 cites W1516408025 @default.
- W2981102012 cites W1520936573 @default.
- W2981102012 cites W1576427485 @default.
- W2981102012 cites W1586484346 @default.
- W2981102012 cites W1604864817 @default.
- W2981102012 cites W1607738011 @default.
- W2981102012 cites W1658932340 @default.
- W2981102012 cites W1903457033 @default.
- W2981102012 cites W1950907231 @default.
- W2981102012 cites W1973996686 @default.
- W2981102012 cites W1976164414 @default.
- W2981102012 cites W1976347223 @default.
- W2981102012 cites W1977505349 @default.
- W2981102012 cites W1978872064 @default.
- W2981102012 cites W1979146135 @default.
- W2981102012 cites W1981807851 @default.
- W2981102012 cites W1984043230 @default.
- W2981102012 cites W1984527841 @default.
- W2981102012 cites W1987990061 @default.
- W2981102012 cites W1989931899 @default.
- W2981102012 cites W1990749803 @default.
- W2981102012 cites W1993971548 @default.
- W2981102012 cites W1994660808 @default.
- W2981102012 cites W1997676278 @default.
- W2981102012 cites W1998594238 @default.
- W2981102012 cites W1999116330 @default.
- W2981102012 cites W2000010950 @default.
- W2981102012 cites W2000361391 @default.
- W2981102012 cites W2002012536 @default.
- W2981102012 cites W2003416699 @default.
- W2981102012 cites W2003472324 @default.
- W2981102012 cites W2003535865 @default.
- W2981102012 cites W2004275877 @default.
- W2981102012 cites W2004543872 @default.
- W2981102012 cites W2008170190 @default.
- W2981102012 cites W2011183628 @default.
- W2981102012 cites W2011528635 @default.
- W2981102012 cites W2015011748 @default.
- W2981102012 cites W2015336564 @default.
- W2981102012 cites W2017091184 @default.
- W2981102012 cites W2017186553 @default.
- W2981102012 cites W2017918524 @default.
- W2981102012 cites W2018858577 @default.
- W2981102012 cites W2022941468 @default.
- W2981102012 cites W2029408895 @default.
- W2981102012 cites W2029682831 @default.
- W2981102012 cites W2029800217 @default.
- W2981102012 cites W2032011914 @default.
- W2981102012 cites W2032896954 @default.
- W2981102012 cites W2033518083 @default.
- W2981102012 cites W2037362692 @default.
- W2981102012 cites W2041089391 @default.
- W2981102012 cites W2041261717 @default.
- W2981102012 cites W2044682044 @default.
- W2981102012 cites W2050373861 @default.
- W2981102012 cites W2058927078 @default.
- W2981102012 cites W2059151197 @default.
- W2981102012 cites W2062117677 @default.
- W2981102012 cites W2063817868 @default.
- W2981102012 cites W2064150989 @default.
- W2981102012 cites W2066321320 @default.
- W2981102012 cites W2067790699 @default.
- W2981102012 cites W2069334549 @default.
- W2981102012 cites W2079731426 @default.
- W2981102012 cites W2083348828 @default.
- W2981102012 cites W2085153618 @default.
- W2981102012 cites W2087991947 @default.
- W2981102012 cites W2093878129 @default.
- W2981102012 cites W2098951793 @default.
- W2981102012 cites W2100539976 @default.
- W2981102012 cites W2100770662 @default.
- W2981102012 cites W2101891297 @default.
- W2981102012 cites W2111485803 @default.
- W2981102012 cites W2113081633 @default.
- W2981102012 cites W2115123250 @default.
- W2981102012 cites W2116471897 @default.
- W2981102012 cites W2119315867 @default.
- W2981102012 cites W2121247753 @default.
- W2981102012 cites W2125369546 @default.
- W2981102012 cites W2125611067 @default.
- W2981102012 cites W2130831435 @default.
- W2981102012 cites W2132958262 @default.
- W2981102012 cites W2132989726 @default.
- W2981102012 cites W2135391430 @default.