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- W2981105257 abstract "The human APOE gene, that codes for apolipoprotein E (apoE), has three major polymorphic alleles: ε2, ε3 and ε4 that give rise to amino acid substitutions. APOE-e4 is a strong risk factor of sporadic Alzheimer's disease (AD) but the reason why is still unknown despite intense research for more than 20 years. The aim of the study was to investigate if the concentrations of total apoE and the specific apoE isoforms in cerebrospinal fluid (CSF) from clinically diagnosed AD, mild cognitive impairment (MCI) and control individuals differed when dichotomized based on the CSF Aβ42/40 cut-off. Quantification of total apoE and specific apoE isoforms in CSF was performed using high-resolution parallel reaction monitoring mass spectrometry. In total, 1214 CSF samples were analyzed in the study (592 β-amyloid-positive and 622 β-amyloid-negative individuals). The differences between two or more independent groups were investigated using Mann-Whitney U or Kruskal-Wallis test, respectively. There was no difference in total apoE or the different apoE isoforms between β-amyloid-positive and -negative groups. However, there was a significant decrease in total apoE with increase of Aβ42/40 from its 1st to its 10th percentile (p=0.006). There was a difference in the concentration between isoforms in heterozygous individuals in an isoform-dependent manner (E2<E3<E4) and the changes were visible in both β-amyloid-positive and -negative groups (p<0.05)." @default.
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- W2981105257 date "2019-07-01" @default.
- W2981105257 modified "2023-10-16" @default.
- W2981105257 title "P4-531: CEREBROSPINAL FLUID APOLIPOPROTEIN E ISOFORM CONCENTRATIONS IN RELATION TO β-AMYLOID POSITIVITY" @default.
- W2981105257 doi "https://doi.org/10.1016/j.jalz.2019.08.078" @default.
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