FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981107229> ?p ?o ?g. }

• W2981107229 abstract "Abstract Background Linoleic acid is the major fatty acid moiety of cardiolipin, which is central to the assembly of components involved in mitochondrial oxidative phosphorylation (OXPHOS). Although linoleic acid is an essential nutrient, its excess intake is harmful to health. On the other hand, linoleic acid has been shown to prevent the reduction in cardiolipin content and to improve mitochondrial function in aged rats with spontaneous hypertensive heart failure (HF). In this study, we found that lower dietary intake of linoleic acid in HF patients statistically correlates with greater severity of HF, and we investigated the mechanisms therein involved. Methods HF patients, who were classified as New York Heart Association (NYHA) functional class I ( n = 45), II ( n = 93), and III ( n = 15), were analyzed regarding their dietary intakes of different fatty acids during the one month prior to the study. Then, using a mouse model of HF, we confirmed reduced cardiolipin levels in their cardiac myocytes, and then analyzed the mechanisms by which dietary supplementation of linoleic acid improves cardiac malfunction of mitochondria. Results The dietary intake of linoleic acid was significantly lower in NYHA III patients, as compared to NYHA II patients. In HF model mice, both CI-based and CII-based OXPHOS activities were affected together with reduced cardiolipin levels. Silencing of CRLS1 , which encodes cardiolipin synthetase, in cultured cardiomyocytes phenocopied these events. Feeding HF mice with linoleic acid improved both CI-based and CII-based respiration as well as left ventricular function, together with an increase in cardiolipin levels. However, although assembly of the respirasome (i.e., CI/CIII 2 /CIV complex), as well as assembly of CII subunits and the CIII 2 /CIV complex statistically correlated with cardiolipin levels in cultured cardiomyocytes, respirasome assembly was not notably restored by dietary linoleic acid in HF mice. Therefore, although linoleic acid may significantly improve both CI-based and CII-based respiration of cardiomyocytes, respirasomes impaired by HF were not easily repaired by the dietary intake of linoleic acid. Conclusions Dietary supplement of linoleic acid is beneficial for improving cardiac malfunction in HF, but is unable to completely cure HF." @default.
• W2981107229 created "2019-10-25" @default.
• W2981107229 creator A5000830028 @default.
• W2981107229 creator A5004951979 @default.
• W2981107229 creator A5007114143 @default.
• W2981107229 creator A5007606729 @default.
• W2981107229 creator A5010878108 @default.
• W2981107229 creator A5025916062 @default.
• W2981107229 creator A5038140688 @default.
• W2981107229 creator A5052476480 @default.
• W2981107229 creator A5054208401 @default.
• W2981107229 creator A5055963608 @default.
• W2981107229 date "2019-10-16" @default.
• W2981107229 modified "2023-10-17" @default.
• W2981107229 title "Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure" @default.
• W2981107229 cites W1558686370 @default.
• W2981107229 cites W1992644002 @default.
• W2981107229 cites W1993534779 @default.
• W2981107229 cites W2050158128 @default.
• W2981107229 cites W2052118720 @default.
• W2981107229 cites W2062339592 @default.
• W2981107229 cites W2067582236 @default.
• W2981107229 cites W2078116832 @default.
• W2981107229 cites W2083822522 @default.
• W2981107229 cites W2093361250 @default.
• W2981107229 cites W2098388347 @default.
• W2981107229 cites W2101891390 @default.
• W2981107229 cites W2108791220 @default.
• W2981107229 cites W2139160649 @default.
• W2981107229 cites W2146665077 @default.
• W2981107229 cites W2153619230 @default.
• W2981107229 cites W2160688542 @default.
• W2981107229 cites W2162503168 @default.
• W2981107229 cites W2170507717 @default.
• W2981107229 cites W2337548936 @default.
• W2981107229 cites W2507486477 @default.
• W2981107229 cites W2510316798 @default.
• W2981107229 cites W2523433664 @default.
• W2981107229 cites W2782405294 @default.
• W2981107229 cites W2889168199 @default.
• W2981107229 cites W2936282674 @default.
• W2981107229 doi "https://doi.org/10.1186/s12964-019-0445-0" @default.
• W2981107229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6796462" @default.
• W2981107229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31619261" @default.
• W2981107229 hasPublicationYear "2019" @default.
• W2981107229 type Work @default.
• W2981107229 sameAs 2981107229 @default.
• W2981107229 citedByCount "26" @default.
• W2981107229 countsByYear W29811072292020 @default.
• W2981107229 countsByYear W29811072292021 @default.
• W2981107229 countsByYear W29811072292022 @default.
• W2981107229 countsByYear W29811072292023 @default.
• W2981107229 crossrefType "journal-article" @default.
• W2981107229 hasAuthorship W2981107229A5000830028 @default.
• W2981107229 hasAuthorship W2981107229A5004951979 @default.
• W2981107229 hasAuthorship W2981107229A5007114143 @default.
• W2981107229 hasAuthorship W2981107229A5007606729 @default.
• W2981107229 hasAuthorship W2981107229A5010878108 @default.
• W2981107229 hasAuthorship W2981107229A5025916062 @default.
• W2981107229 hasAuthorship W2981107229A5038140688 @default.
• W2981107229 hasAuthorship W2981107229A5052476480 @default.
• W2981107229 hasAuthorship W2981107229A5054208401 @default.
• W2981107229 hasAuthorship W2981107229A5055963608 @default.
• W2981107229 hasBestOaLocation W29811072291 @default.
• W2981107229 hasConcept C126322002 @default.
• W2981107229 hasConcept C134018914 @default.
• W2981107229 hasConcept C185592680 @default.
• W2981107229 hasConcept C2778198053 @default.
• W2981107229 hasConcept C2778918659 @default.
• W2981107229 hasConcept C2780809830 @default.
• W2981107229 hasConcept C2781302388 @default.
• W2981107229 hasConcept C28859421 @default.
• W2981107229 hasConcept C41625074 @default.
• W2981107229 hasConcept C543025807 @default.
• W2981107229 hasConcept C55493867 @default.
• W2981107229 hasConcept C57600042 @default.
• W2981107229 hasConcept C71924100 @default.
• W2981107229 hasConceptScore W2981107229C126322002 @default.
• W2981107229 hasConceptScore W2981107229C134018914 @default.
• W2981107229 hasConceptScore W2981107229C185592680 @default.
• W2981107229 hasConceptScore W2981107229C2778198053 @default.
• W2981107229 hasConceptScore W2981107229C2778918659 @default.
• W2981107229 hasConceptScore W2981107229C2780809830 @default.
• W2981107229 hasConceptScore W2981107229C2781302388 @default.
• W2981107229 hasConceptScore W2981107229C28859421 @default.
• W2981107229 hasConceptScore W2981107229C41625074 @default.
• W2981107229 hasConceptScore W2981107229C543025807 @default.
• W2981107229 hasConceptScore W2981107229C55493867 @default.
• W2981107229 hasConceptScore W2981107229C57600042 @default.
• W2981107229 hasConceptScore W2981107229C71924100 @default.
• W2981107229 hasIssue "1" @default.
• W2981107229 hasLocation W29811072291 @default.
• W2981107229 hasLocation W29811072292 @default.
• W2981107229 hasLocation W29811072293 @default.
• W2981107229 hasLocation W29811072294 @default.
• W2981107229 hasOpenAccess W2981107229 @default.
• W2981107229 hasPrimaryLocation W29811072291 @default.
• W2981107229 hasRelatedWork W1531251285 @default.
• W2981107229 hasRelatedWork W1586704473 @default.
• W2981107229 hasRelatedWork W1977297750 @default.

• next