Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981144559> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2981144559 abstract "As much as 2% of the general population will undergo corticosteroid therapy at some point in their lives - the side effects of which are extensive and, at times, severe. Among these side effects are marked learning and memory (LM) impairments. There is considerable evidence that LM is modulated in a circadian manner. Molecular clock machinery (MCM) is responsible for 24hr cycles of cellular, physiological and behavioural activity, and is composed of a series of tightly regulated transcriptional-translational feedback loops - entrained by the suprachiasmatic nucleus of the hypothalamus and maintained in peripheral tissues via endogenous glucocorticoid signalling. Synthetic corticosteroids have a longer half-life than endogenous corticosteroids, and have been shown to dysregulate: a) ultradian patterns of transcription, and b) the MCM in several peripheral tissues - via the endogenous corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). We have taken hippocampus and perirhinal cortex (PrhCx) from vehicle and methyl-prednisolone- (MPL) treated Lister-Hooded rats every 4hrs across a 24hr period. By interrogating a hippocampal RNA-sequencing dataset from this paradigm, we identified that 28/66 gene transcripts (identified as “glucocorticoid regulated” or “following circadian patterns of expression” in literature) were found to have significant differences: a) over the 24hr period, or b) following MPL treatment. Using real-time qPCR, we are the first to show oscillations of eight key clock genes in the PrhCx over the photoperiod, alongside the gene-specific dysregulation of these clock genes (at each timepoint) during chronic MPL treatment. In a separate experiment, we have shown differential GR:MR binding dynamics at GR regulatory elements (GREs) in the glucocorticoid target genes Per1 and Fkbp5. This preliminary research will inform vital future research into the molecular mechanisms underlying LM impairments and how best to attenuate these." @default.
- W2981144559 created "2019-10-25" @default.
- W2981144559 creator A5075184589 @default.
- W2981144559 date "2017-01-01" @default.
- W2981144559 modified "2023-09-27" @default.
- W2981144559 title "Circadian rhythmicity in hippocampus and perirhinal cortex is dysregulated during chronic methyl-prednisolone treatment" @default.
- W2981144559 hasPublicationYear "2017" @default.
- W2981144559 type Work @default.
- W2981144559 sameAs 2981144559 @default.
- W2981144559 citedByCount "0" @default.
- W2981144559 crossrefType "dissertation" @default.
- W2981144559 hasAuthorship W2981144559A5075184589 @default.
- W2981144559 hasConcept C121446783 @default.
- W2981144559 hasConcept C126322002 @default.
- W2981144559 hasConcept C134018914 @default.
- W2981144559 hasConcept C148762608 @default.
- W2981144559 hasConcept C169760540 @default.
- W2981144559 hasConcept C184738001 @default.
- W2981144559 hasConcept C2778186239 @default.
- W2981144559 hasConcept C2778317145 @default.
- W2981144559 hasConcept C2780352252 @default.
- W2981144559 hasConcept C2780360009 @default.
- W2981144559 hasConcept C2780841215 @default.
- W2981144559 hasConcept C2781099131 @default.
- W2981144559 hasConcept C2781161787 @default.
- W2981144559 hasConcept C38606739 @default.
- W2981144559 hasConcept C59493245 @default.
- W2981144559 hasConcept C71315377 @default.
- W2981144559 hasConcept C71924100 @default.
- W2981144559 hasConcept C86803240 @default.
- W2981144559 hasConceptScore W2981144559C121446783 @default.
- W2981144559 hasConceptScore W2981144559C126322002 @default.
- W2981144559 hasConceptScore W2981144559C134018914 @default.
- W2981144559 hasConceptScore W2981144559C148762608 @default.
- W2981144559 hasConceptScore W2981144559C169760540 @default.
- W2981144559 hasConceptScore W2981144559C184738001 @default.
- W2981144559 hasConceptScore W2981144559C2778186239 @default.
- W2981144559 hasConceptScore W2981144559C2778317145 @default.
- W2981144559 hasConceptScore W2981144559C2780352252 @default.
- W2981144559 hasConceptScore W2981144559C2780360009 @default.
- W2981144559 hasConceptScore W2981144559C2780841215 @default.
- W2981144559 hasConceptScore W2981144559C2781099131 @default.
- W2981144559 hasConceptScore W2981144559C2781161787 @default.
- W2981144559 hasConceptScore W2981144559C38606739 @default.
- W2981144559 hasConceptScore W2981144559C59493245 @default.
- W2981144559 hasConceptScore W2981144559C71315377 @default.
- W2981144559 hasConceptScore W2981144559C71924100 @default.
- W2981144559 hasConceptScore W2981144559C86803240 @default.
- W2981144559 hasLocation W29811445591 @default.
- W2981144559 hasOpenAccess W2981144559 @default.
- W2981144559 hasPrimaryLocation W29811445591 @default.
- W2981144559 hasRelatedWork W1837114591 @default.
- W2981144559 hasRelatedWork W1985604755 @default.
- W2981144559 hasRelatedWork W1998522501 @default.
- W2981144559 hasRelatedWork W2034312395 @default.
- W2981144559 hasRelatedWork W2042336558 @default.
- W2981144559 hasRelatedWork W2064394849 @default.
- W2981144559 hasRelatedWork W2115259828 @default.
- W2981144559 hasRelatedWork W2127035635 @default.
- W2981144559 hasRelatedWork W2130826497 @default.
- W2981144559 hasRelatedWork W2164389297 @default.
- W2981144559 hasRelatedWork W2186560067 @default.
- W2981144559 hasRelatedWork W2253206351 @default.
- W2981144559 hasRelatedWork W2361333928 @default.
- W2981144559 hasRelatedWork W2728697871 @default.
- W2981144559 hasRelatedWork W2767541991 @default.
- W2981144559 hasRelatedWork W2963367907 @default.
- W2981144559 hasRelatedWork W2969765673 @default.
- W2981144559 hasRelatedWork W2982509876 @default.
- W2981144559 hasRelatedWork W2983744555 @default.
- W2981144559 hasRelatedWork W3210521906 @default.
- W2981144559 isParatext "false" @default.
- W2981144559 isRetracted "false" @default.
- W2981144559 magId "2981144559" @default.
- W2981144559 workType "dissertation" @default.