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• W2981147924 abstract "Purpose To determine the role of IQ-domain GTPase-activating protein1 (IQGAP-1) in tight junctions of human corneal epithelial cells (HCECs) and its effect against P. aeruginosa (PAK) invasion.Material and Methods Primary human corneal epithelial cells (HCECs), immortalized HCECs, and IQGAP-1 RNA knockdown HCECs (siHCECs) were used. Confocal microscopy, transepithelial electrical resistance (TER), trypan blue exclusion assay and gentamicin invasion assay were done.Results In primary and immortalized HCECs, IQGAP-1 co-localized with zonular occludin-1 (ZO-1) and actin. Enhanced actin and ZO-1 aggregation were seen in siHCECs. IQGAP-1 knockdown significantly increased TER of immortalized HCECs (P < .0001). Cell viability after PAK infection increased for siHCECs for up to 4 h after infection. PAK intracellular invasion was significantly lowered by 50% in siHCECs at 1 h post-infection.Conclusion IQGAP-1 knockdown increased the strength and integrity of tight junctions and may provide an early protective effect against P. aeruginosa invasion." @default.
• W2981147924 created "2019-10-25" @default.
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• W2981147924 date "2019-10-17" @default.
• W2981147924 modified "2023-10-16" @default.
• W2981147924 title "Knockdown of IQGAP-1 Enhances Tight Junctions and Prevents <i>P. aeruginosa</i> Invasion of Human Corneal Epithelial Cells" @default.
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• W2981147924 doi "https://doi.org/10.1080/09273948.2019.1642494" @default.
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