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- W2981158621 abstract "There is 35% misdiagnosis of dementia even among specialists and knowledge of amyloid Positron Emission Tomography (PET) results led to diagnostic shift from Alzheimer's Disease (AD) to non-AD and vice versa with change in management in up to 63%. Amyloid PET is not widely available and accessible. Multimer Detection System (MDS) detects plasma oligomeric amyloid beta (OAβ) with discriminative accuracy in comparable with amyloid PET. We investigated whether MDS-OAβ could differentiate AD from other dementia etiologies. This cross-sectional study of 212 patients evaluated in a specialized memory clinic from Jan 2018 to March 2019 with full neuropsychological assessment and magnetic resonance imaging. Results of MDS-OAβ were not available at the time of diagnosis. Diagnoses were grouped into a) no cognitive impairment/subjective cognitive impairment (NCI/SCI), b) AD, c) non-AD (vascular dementia [VAD], frontotemporal dementia, Parkinson's disease dementia, progressive supranuclear palsy, corticobasal degeneration, and depression), d) mixed AD-VAD, and e) undetermined etiology. One-way ANOVA was used to determine the difference in MDS-OAβ ratio and characteristics across the different groups. Fisher's Least Significant Difference and Bonferroni tests were used for post-hoc analysis. Of the 212 patients, 151 MDS-OAβ results were available. Mean age was 75.08 ± 10.04 years and 96 (64%) were female. Diagnosis were AD (47.7%), non-AD patients (21.2%), mixed AD-VAD (19.2%), NCI/SCI (9.3%) and undetermined etiology (2.6%). Majority were in the mild stage, CDR 0.5 (58.3%) and CDR 1 (23.8%). Hippocampal volume was smallest in mixed AD-VAD and Fazekas rating was highest in mixed AD-VAD. (Table 1) The groups were significantly different from each other in age, hippocampal volume, Fazekas rating and MDS-OAβ ratio and post-hoc analysis showed that MDS-OAβ ratio at a previously determined level of 1.1 was not significantly different between AD and mixed AD-VAD (p>0.05) but both groups were significantly different from the NCI/SCI (p<0.001) and from the non-AD (p<0.01) group. (Figure 1)" @default.
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- W2981158621 date "2019-07-01" @default.
- W2981158621 modified "2023-10-06" @default.
- W2981158621 title "P4-549: PLASMA-BASED BIOMARKER MDS-OAβ DIFFERENTIATES ALZHEIMER'S DISEASE FROM OTHER ETIOLOGIES" @default.
- W2981158621 doi "https://doi.org/10.1016/j.jalz.2019.08.096" @default.
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