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• W2981196090 abstract "The present study provides molecular and functional characterization of Na + -K + -2Cl − cotransporter (NKCC1/Slc12a2) in the gills of sea lamprey ( Petromyzon marinus), the most basal extant vertebrate with an osmoregulatory strategy. We report the full-length peptide sequence for the lamprey Na-K-Cl cotransporter 1 (NKCC1), which we show groups strongly with and occupies a basal position among other vertebrate NKCC1 sequences. In postmetamorphic juvenile lamprey, nkcc1 mRNA was present in many tissues but was fivefold higher in the gill than any other examined tissue, and NKCC1 protein was only detected in the gill. Gill mRNA and protein abundances of NKCC1 and Na + -K + -ATPase (NKA/Atp1a1) were significantly upregulated (20- to 200-fold) during late metamorphosis in fresh water, coinciding with the development of salinity tolerance, and were upregulated an additional twofold after acclimation to seawater (SW). Immunohistochemistry revealed that NKCC1 in the gill is found in filamental ionocytes coexpressing NKA, which develop during metamorphosis in preparation for SW entry. Lamprey treated with bumetanide, a widely used pharmacological inhibitor of NKCC1, exhibited higher plasma Cl − and osmolality as well as reduced muscle water content after 24 h in SW; there were no effects of bumetanide in freshwater-acclimated lamprey. This work provides the first functional characterization of NKCC1 as a mechanism for branchial salt secretion in lampreys, providing evidence that this mode of Cl − secretion has been present among vertebrates for ~550 million years." @default.
• W2981196090 created "2019-10-25" @default.
• W2981196090 creator A5035816498 @default.
• W2981196090 creator A5054146102 @default.
• W2981196090 date "2020-01-01" @default.
• W2981196090 modified "2023-10-03" @default.
• W2981196090 title "Functional characterization and osmoregulatory role of the Na⁺-K⁺-2Cl⁻cotransporter in the gill of sea lamprey (<i>Petromyzon marinus</i>), a basal vertebrate" @default.
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• W2981196090 doi "https://doi.org/10.1152/ajpregu.00125.2019" @default.
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