FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981200867> ?p ?o ?g. }

• W2981200867 endingPage "110901" @default.
• W2981200867 startingPage "110901" @default.
• W2981200867 abstract "Transferrin, the major iron transport protein in the blood, apparently also transports trivalent chromium in vivo via endocytosis. Recent in vitro studies have, however, suggested that the release of chromic ions from serum transferrin is too slow to be biologically relevant. Consequently, the release of chromium(III) from human serum transferrin has been examined under conditions mimicking an endosome during endocytosis. At pH 4.5 and 5.5, the release of Cr(III) from transferrin occurs rapidly from the weak binding site. While appreciably slower, the release of Cr(III) from the tighter site in the presence of biological chelating agents is potentially sufficiently fast to be physiologically relevant. When Cr(III)-loaded transferrin is added to soluble transferrin receptor, the interaction with the receptor results in Cr(III) in both the weak and tight binding sites giving rise to an EPR signal similar to that of the weak binding site; concurrently, the loss of Cr(III) from both binding sites becomes rapid at acidic pH, more rapid than from either site in the absence of the receptor. Loss of Cr(III) from the transferrin-transferrin receptor complex, thus, is easily sufficiently rapid for transferrin to serve as the physiological transporter of Cr(III) from the bloodstream to the tissues. However, detailed studies of conformational changes of transferrin associated with the binding and release of chromium along with investigations of how and at what rate Cr(III) is transported from the endosome will be required before this question of whether transferrin transport Cr(III) in vivo can be definitively resolved." @default.
• W2981200867 created "2019-10-25" @default.
• W2981200867 creator A5014421361 @default.
• W2981200867 creator A5018920999 @default.
• W2981200867 creator A5082827028 @default.
• W2981200867 date "2020-01-01" @default.
• W2981200867 modified "2023-09-26" @default.
• W2981200867 title "Release of trivalent chromium from serum transferrin is sufficiently rapid to be physiologically relevant" @default.
• W2981200867 cites W1510134239 @default.
• W2981200867 cites W1557894700 @default.
• W2981200867 cites W1973445792 @default.
• W2981200867 cites W1978417764 @default.
• W2981200867 cites W1996133874 @default.
• W2981200867 cites W1999946223 @default.
• W2981200867 cites W2011315858 @default.
• W2981200867 cites W2022573972 @default.
• W2981200867 cites W2025019338 @default.
• W2981200867 cites W2027076158 @default.
• W2981200867 cites W2036156503 @default.
• W2981200867 cites W2036233460 @default.
• W2981200867 cites W2037016852 @default.
• W2981200867 cites W2037914722 @default.
• W2981200867 cites W2062511487 @default.
• W2981200867 cites W2062565319 @default.
• W2981200867 cites W2067334088 @default.
• W2981200867 cites W2070707407 @default.
• W2981200867 cites W2079264862 @default.
• W2981200867 cites W2079283592 @default.
• W2981200867 cites W2083176161 @default.
• W2981200867 cites W2084392651 @default.
• W2981200867 cites W2093083236 @default.
• W2981200867 cites W2098982261 @default.
• W2981200867 cites W2111671928 @default.
• W2981200867 cites W2137130769 @default.
• W2981200867 cites W2168442241 @default.
• W2981200867 cites W2406525949 @default.
• W2981200867 cites W2508152588 @default.
• W2981200867 cites W2939133064 @default.
• W2981200867 doi "https://doi.org/10.1016/j.jinorgbio.2019.110901" @default.
• W2981200867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31669693" @default.
• W2981200867 hasPublicationYear "2020" @default.
• W2981200867 type Work @default.
• W2981200867 sameAs 2981200867 @default.
• W2981200867 citedByCount "14" @default.
• W2981200867 countsByYear W29812008672020 @default.
• W2981200867 countsByYear W29812008672021 @default.
• W2981200867 countsByYear W29812008672022 @default.
• W2981200867 countsByYear W29812008672023 @default.
• W2981200867 crossrefType "journal-article" @default.
• W2981200867 hasAuthorship W2981200867A5014421361 @default.
• W2981200867 hasAuthorship W2981200867A5018920999 @default.
• W2981200867 hasAuthorship W2981200867A5082827028 @default.
• W2981200867 hasConcept C102747710 @default.
• W2981200867 hasConcept C104317684 @default.
• W2981200867 hasConcept C107824862 @default.
• W2981200867 hasConcept C12554922 @default.
• W2981200867 hasConcept C149011108 @default.
• W2981200867 hasConcept C150903083 @default.
• W2981200867 hasConcept C170493617 @default.
• W2981200867 hasConcept C178790620 @default.
• W2981200867 hasConcept C185592680 @default.
• W2981200867 hasConcept C202751555 @default.
• W2981200867 hasConcept C207001950 @default.
• W2981200867 hasConcept C22814914 @default.
• W2981200867 hasConcept C28005876 @default.
• W2981200867 hasConcept C32264632 @default.
• W2981200867 hasConcept C511782168 @default.
• W2981200867 hasConcept C55493867 @default.
• W2981200867 hasConcept C86803240 @default.
• W2981200867 hasConceptScore W2981200867C102747710 @default.
• W2981200867 hasConceptScore W2981200867C104317684 @default.
• W2981200867 hasConceptScore W2981200867C107824862 @default.
• W2981200867 hasConceptScore W2981200867C12554922 @default.
• W2981200867 hasConceptScore W2981200867C149011108 @default.
• W2981200867 hasConceptScore W2981200867C150903083 @default.
• W2981200867 hasConceptScore W2981200867C170493617 @default.
• W2981200867 hasConceptScore W2981200867C178790620 @default.
• W2981200867 hasConceptScore W2981200867C185592680 @default.
• W2981200867 hasConceptScore W2981200867C202751555 @default.
• W2981200867 hasConceptScore W2981200867C207001950 @default.
• W2981200867 hasConceptScore W2981200867C22814914 @default.
• W2981200867 hasConceptScore W2981200867C28005876 @default.
• W2981200867 hasConceptScore W2981200867C32264632 @default.
• W2981200867 hasConceptScore W2981200867C511782168 @default.
• W2981200867 hasConceptScore W2981200867C55493867 @default.
• W2981200867 hasConceptScore W2981200867C86803240 @default.
• W2981200867 hasFunder F4320306106 @default.
• W2981200867 hasFunder F4320312852 @default.
• W2981200867 hasLocation W29812008671 @default.
• W2981200867 hasOpenAccess W2981200867 @default.
• W2981200867 hasPrimaryLocation W29812008671 @default.
• W2981200867 hasRelatedWork W1975765794 @default.
• W2981200867 hasRelatedWork W1978891093 @default.
• W2981200867 hasRelatedWork W1987003753 @default.
• W2981200867 hasRelatedWork W2008738197 @default.
• W2981200867 hasRelatedWork W2059956955 @default.
• W2981200867 hasRelatedWork W2072705032 @default.
• W2981200867 hasRelatedWork W2098982261 @default.

• next