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- W2981230870 abstract "18F-MK-6240 is a PET radioligand recently developed to measure tau pathology in Alzheimer's disease (AD). We sought to evaluate the ability of this radioligand to identify different patterns of tau pathology in clinical AD patients and older controls. Forty-three participants (age 69.8 ± 8.0 years) underwent neuropsychological testing, brain MRI, 18F-florbetaben to measure amyloid, and 18F-MK-6240 to measure tau pathology. Twenty-four met clinical criteria for either amnestic mild cognitive impairment or mild AD, and 19 were cognitively normal. For 18F-MK-6240 analysis, partial volume correction was applied using the region-based voxelwise method, and inferior cerebellar gray matter was used as reference region to calculate standardized uptake value ratios (SUVRs). Of seven amyloid-positive controls included, three had visually evident increase in 18F-MK-6240 binding in medial temporal cortex (Fig 1A), with SUVRs > 2. These “tau-positive” controls had smaller hippocampal volumes than other amyloid-positive controls (0.76% - 0.88% vs.1.08% - 1.20% total intracranial volume). Out of 14 amyloid-positive patients, two had 18F-MK6240 binding in medial temporal cortex much lower than expected (SUVRs of 1.71 and 1.99 vs. 3.44 - 5.48 for remaining amyloid-positive patients). One of these patients had high 18F-MK-6240 binding in neocortex, presented at an early age (53 years), was male, and had relatively large hippocampal volume compared to other amyloid-positive controls (1.0% vs 0.87 ± 0.15% total intracranial volume, Fig 1B). This case may represent hippocampal-sparing AD, an atypical neuropathological subtype more frequently seen in males and in younger patients. The other amyloid-positive patient lacking medial temporal 18F-MK-6240 binding was older (78 years) and had low binding throughout the brain, despite small hippocampal volume (0.50% total intracranial volume, Fig 1C). This case may represent an amyloid pathophysiological process with a concomitant non-tau copathology (A+T-N+). Out of 10 amyloid-negative patients, only one had evident 18F-MK-6240 binding in medial temporal cortex in range of amyloid-positive patients (SUVR = 3.14, Fig 1D). This case may represent primary age related tauopathy (PART)." @default.
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- W2981230870 date "2019-07-01" @default.
- W2981230870 modified "2023-10-02" @default.
- W2981230870 title "IC-P-169: PATTERNS OF TAU PATHOLOGY IDENTIFIED WITH 18 F-MK-6240 PET IMAGING" @default.
- W2981230870 doi "https://doi.org/10.1016/j.jalz.2019.06.4284" @default.
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