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- W2981282613 abstract "Numerous studies show that sensitivity to stress increases the risk for Alzheimer's disease (AD), with mechanisms related to increased glucorticoid exposure presumed to underlie this association. Meanwhile, the mechanisms by which the single largest genetic risk factor for sporadic AD—the apolipoprotein E (APOE) ε4 allele— is thought to increase AD risk via its role in factors associated with regulating lipid transport. We propose that this gene may also exert its effects on AD risk by influencing glucocorticoid activity. Although the presence of APOE ε4 is associated with increased stress hormone (cortisol) levels in older adults and in those with AD, such findings might be attributable to the effects of incipient AD on stress hormone levels. We hypothesized that if variants in the APOE gene pose a risk for AD due to mechanisms related to glucocorticoid activity, then this association should be evident much earlier in the lifespan. In 413 healthy adults (18 – 29 years; 279 women), we measured salivary stress hormones at 3 time points before and 5 time points after an acute stressor (the Trier Social Stress Test). After excluding 9 individuals with the APOE 2/4 genotype, we compared salivary cortisol levels among three groups based on number of APOE ε4 alleles (0, 1, or 2) in a repeated-measures analysis of covariance controlling for sex and race. We also analyzed various parameters of the cortisol stress response, including area under the curve, and change in cortisol in response to stress. Individuals who were homozygous for the APOE ε4 allele (n=8) had higher cortisol levels at baseline and following the acute stressor than did those with either 1 (n=90) or 0 (n=306) ε4 alleles (F=4.49; p=.01); individuals with 1 APOE ε4 allele did not differ from those with 0 ε4 alleles (see Figure)." @default.
- W2981282613 created "2019-10-25" @default.
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- W2981282613 date "2019-07-01" @default.
- W2981282613 modified "2023-10-07" @default.
- W2981282613 title "P4-569: APOE GENETIC VARIANTS ARE ASSOCIATED WITH STRESS HORMONE LEVELS IN YOUNG ADULTHOOD" @default.
- W2981282613 doi "https://doi.org/10.1016/j.jalz.2019.08.116" @default.
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