FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981283786> ?p ?o ?g. }

• W2981283786 endingPage "889" @default.
• W2981283786 startingPage "853" @default.
• W2981283786 abstract "Key points In central regions of vestibular semicircular canal epithelia, the [K + ] in the synaptic cleft ([K + ] c ) contributes to setting the hair cell and afferent membrane potentials; the potassium efflux from type I hair cells results from the interdependent gating of three conductances. Elevation of [K + ] c occurs through a calcium‐activated potassium conductance, G BK , and a low‐voltage‐activating delayed rectifier, G K(LV) , that activates upon elevation of [K + ] c . Calcium influx that enables quantal transmission also activates I BK , an effect that can be blocked internally by BAPTA, and externally by a Ca V 1.3 antagonist or iberiotoxin. Elevation of [K + ] c or chelation of [Ca 2+ ] c linearizes the G K(LV) steady‐state I–V curve, suggesting that the outward rectification observed for G K(LV) may result largely from a potassium‐sensitive relief of Ca 2+ inactivation of the channel pore selectivity filter. Potassium sensitivity of hair cell and afferent conductances allows three modes of transmission: quantal, ion accumulation and resistive coupling to be multiplexed across the synapse. Abstract In the vertebrate nervous system, ions accumulate in diffusion‐limited synaptic clefts during ongoing activity. Such accumulation can be demonstrated at large appositions such as the hair cell–calyx afferent synapses present in central regions of the turtle vestibular semicircular canal epithelia. Type I hair cells influence discharge rates in their calyx afferents by modulating the potassium concentration in the synaptic cleft, [K + ] c , which regulates potassium‐sensitive conductances in both hair cell and afferent. Dual recordings from synaptic pairs have demonstrated that, despite a decreased driving force due to potassium accumulation, hair cell depolarization elicits sustained outward currents in the hair cell, and a maintained inward current in the afferent. We used kinetic and pharmacological dissection of the hair cell conductances to understand the interdependence of channel gating and permeation in the context of such restricted extracellular spaces. Hair cell depolarization leads to calcium influx and activation of a large calcium‐activated potassium conductance, G BK , that can be blocked by agents that disrupt calcium influx or buffer the elevation of [Ca 2+ ] i , as well as by the specific K Ca 1.1 blocker iberiotoxin. Efflux of K + through G BK can rapidly elevate [K + ] c , which speeds the activation and slows the inactivation and deactivation of a second potassium conductance, G K(LV) . Elevation of [K + ] c or chelation of [Ca 2+ ] c linearizes the G K(LV) steady‐state I–V curve, consistent with a K + ‐dependent relief of Ca 2+ inactivation of G K(LV) . As a result, this potassium‐sensitive hair cell conductance pairs with the potassium‐sensitive hyperpolarization‐activated cyclic nucleotide‐gated channel (HCN) conductance in the afferent and creates resistive coupling at the synaptic cleft." @default.
• W2981283786 created "2019-10-25" @default.
• W2981283786 creator A5023156010 @default.
• W2981283786 creator A5050229496 @default.
• W2981283786 creator A5071425518 @default.
• W2981283786 date "2019-11-29" @default.
• W2981283786 modified "2023-09-26" @default.
• W2981283786 title "Synaptic cleft microenvironment influences potassium permeation and synaptic transmission in hair cells surrounded by calyx afferents in the turtle" @default.
• W2981283786 cites W1495154679 @default.
• W2981283786 cites W1521440171 @default.
• W2981283786 cites W1555733423 @default.
• W2981283786 cites W1580315781 @default.
• W2981283786 cites W1628979938 @default.
• W2981283786 cites W1889733078 @default.
• W2981283786 cites W1963730490 @default.
• W2981283786 cites W1969870358 @default.
• W2981283786 cites W1971406825 @default.
• W2981283786 cites W1972246035 @default.
• W2981283786 cites W1975038016 @default.
• W2981283786 cites W1975178727 @default.
• W2981283786 cites W1976505330 @default.
• W2981283786 cites W1979400171 @default.
• W2981283786 cites W1981683941 @default.
• W2981283786 cites W1982682966 @default.
• W2981283786 cites W1983952636 @default.
• W2981283786 cites W1987211464 @default.
• W2981283786 cites W1990717776 @default.
• W2981283786 cites W1991357993 @default.
• W2981283786 cites W1991690011 @default.
• W2981283786 cites W1996759313 @default.
• W2981283786 cites W1997772472 @default.
• W2981283786 cites W1997836778 @default.
• W2981283786 cites W1998053502 @default.
• W2981283786 cites W2001319941 @default.
• W2981283786 cites W2005919259 @default.
• W2981283786 cites W2005954145 @default.
• W2981283786 cites W2009096910 @default.
• W2981283786 cites W2009855270 @default.
• W2981283786 cites W2010415181 @default.
• W2981283786 cites W2014899976 @default.
• W2981283786 cites W2016353732 @default.
• W2981283786 cites W2017441152 @default.
• W2981283786 cites W2019374116 @default.
• W2981283786 cites W2021636027 @default.
• W2981283786 cites W2021742608 @default.
• W2981283786 cites W2022253074 @default.
• W2981283786 cites W2024905669 @default.
• W2981283786 cites W2026815132 @default.
• W2981283786 cites W2027138703 @default.
• W2981283786 cites W2027614529 @default.
• W2981283786 cites W2029715006 @default.
• W2981283786 cites W2032077935 @default.
• W2981283786 cites W2034817982 @default.
• W2981283786 cites W2036776853 @default.
• W2981283786 cites W2037099564 @default.
• W2981283786 cites W2043211010 @default.
• W2981283786 cites W2044157650 @default.
• W2981283786 cites W2045476870 @default.
• W2981283786 cites W2049879893 @default.
• W2981283786 cites W2055252729 @default.
• W2981283786 cites W2055505580 @default.
• W2981283786 cites W2057637188 @default.
• W2981283786 cites W2057654256 @default.
• W2981283786 cites W2057987566 @default.
• W2981283786 cites W2058535047 @default.
• W2981283786 cites W2060988973 @default.
• W2981283786 cites W2067312729 @default.
• W2981283786 cites W2067822038 @default.
• W2981283786 cites W2072185811 @default.
• W2981283786 cites W2073268852 @default.
• W2981283786 cites W2073607158 @default.
• W2981283786 cites W2074527323 @default.
• W2981283786 cites W2077932410 @default.
• W2981283786 cites W2079453878 @default.
• W2981283786 cites W2081299190 @default.
• W2981283786 cites W2081815012 @default.
• W2981283786 cites W2082585200 @default.
• W2981283786 cites W2084657878 @default.
• W2981283786 cites W2088901750 @default.
• W2981283786 cites W2093103992 @default.
• W2981283786 cites W2093660899 @default.
• W2981283786 cites W2095529674 @default.
• W2981283786 cites W2097400197 @default.
• W2981283786 cites W2100014574 @default.
• W2981283786 cites W2100020529 @default.
• W2981283786 cites W2103673901 @default.
• W2981283786 cites W2105752803 @default.
• W2981283786 cites W2110479875 @default.
• W2981283786 cites W2117788987 @default.
• W2981283786 cites W2118298051 @default.
• W2981283786 cites W2120492735 @default.
• W2981283786 cites W2120741241 @default.
• W2981283786 cites W2123521142 @default.
• W2981283786 cites W2129844520 @default.
• W2981283786 cites W2133464980 @default.
• W2981283786 cites W2134186721 @default.
• W2981283786 cites W2140021174 @default.
• W2981283786 cites W2141010671 @default.

• next