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- W2981359097 abstract "Extra-skeletal manifestations (EMs) of ankylosing spondylitis (AS) can occur and proceed in parallel with inflammatory changes in the joints and spine and often dominate in the clinical picture of AS, determining its high activity and significantly worsening the quality of life in patients. In a number of cases, EMs are characterized by an insufficient response to standard anti-inflammatory therapy for back pain, arthritis, and enthesitis; and there is a need to prescribe another class of drugs. The review highlights the results of studies evaluating the efficacy of golimumab (GLM) in treating EMs in patients with AS: uveitis (GO-EASY Study) and ulcerative colitis (UC) (PURSUIT-SC, PURSUIT-M studies). Analysis of these studies have shown the high efficacy and safety of GLM in reducing the clinical manifestations of AS and in preventing the exacerbations of uveitis and UC. However, despite the successes achieved in treating AS and its EMs, there are many unresolved issues, including those related to the elaboration of optimal treatment regimens, which required longer observational studies with a large sample size." @default.
- W2981359097 created "2019-11-01" @default.
- W2981359097 creator A5067571701 @default.
- W2981359097 date "2019-10-23" @default.
- W2981359097 modified "2023-10-05" @default.
- W2981359097 title "Golimumab in the treatment of extra-skeletal manifestations of ankylosing spondylitis" @default.
- W2981359097 doi "https://doi.org/10.14412/1996-7012-2019-4-110-115" @default.
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