Matches in SemOpenAlex for { <https://semopenalex.org/work/W2981365785> ?p ?o ?g. }
- W2981365785 abstract "The recruitment of RNA polymerase II (Pol II) to core promoters is highly regulated during rapid induction of genes. In response to heat shock, heat shock transcription factor 1 (HSF1) is activated and occupies heat shock gene promoters. Promoter-bound HSF1 recruits general transcription factors and Mediator, which interact with Pol II, but stress-specific mechanisms of Pol II recruitment are unclear. Here, we show in comparative analyses of HSF1 paralogs and their mutants that HSF1 interacts with the pericentromeric adaptor protein shugoshin 2 (SGO2) during heat shock in mouse cells, in a manner dependent on inducible phosphorylation of HSF1 at serine 326, and recruits SGO2 to the HSP70 promoter. SGO2-mediated binding and recruitment of Pol II with a hypophosphorylated C-terminal domain promote expression of HSP70, implicating SGO2 as one of the coactivators that facilitate Pol II recruitment by HSF1. Furthermore, the HSF1-SGO2 complex supports cell survival and maintenance of proteostasis in heat shock conditions. These results exemplify a proteotoxic stress-specific mechanism of Pol II recruitment, which is triggered by phosphorylation of HSF1 during the heat shock response." @default.
- W2981365785 created "2019-11-01" @default.
- W2981365785 creator A5004693769 @default.
- W2981365785 creator A5016788980 @default.
- W2981365785 creator A5035787308 @default.
- W2981365785 creator A5043931681 @default.
- W2981365785 creator A5047490704 @default.
- W2981365785 creator A5083614681 @default.
- W2981365785 creator A5088564846 @default.
- W2981365785 date "2019-10-28" @default.
- W2981365785 modified "2023-10-17" @default.
- W2981365785 title "The pericentromeric protein shugoshin 2 cooperates with<scp>HSF</scp>1 in heat shock response and<scp>RNA</scp>Pol<scp>II</scp>recruitment" @default.
- W2981365785 cites W1529357822 @default.
- W2981365785 cites W1529558120 @default.
- W2981365785 cites W1534544091 @default.
- W2981365785 cites W1539559164 @default.
- W2981365785 cites W1541948779 @default.
- W2981365785 cites W1862677589 @default.
- W2981365785 cites W1881688083 @default.
- W2981365785 cites W1933920814 @default.
- W2981365785 cites W1954249603 @default.
- W2981365785 cites W1965151695 @default.
- W2981365785 cites W1967138582 @default.
- W2981365785 cites W1969735755 @default.
- W2981365785 cites W1973036877 @default.
- W2981365785 cites W1974631225 @default.
- W2981365785 cites W1980291812 @default.
- W2981365785 cites W1981276526 @default.
- W2981365785 cites W1985034089 @default.
- W2981365785 cites W1992428272 @default.
- W2981365785 cites W1992439030 @default.
- W2981365785 cites W1992491954 @default.
- W2981365785 cites W1993243592 @default.
- W2981365785 cites W1993413544 @default.
- W2981365785 cites W1997205980 @default.
- W2981365785 cites W2007227478 @default.
- W2981365785 cites W2010699331 @default.
- W2981365785 cites W2012451954 @default.
- W2981365785 cites W2017844161 @default.
- W2981365785 cites W2018134526 @default.
- W2981365785 cites W2019041692 @default.
- W2981365785 cites W2019638339 @default.
- W2981365785 cites W2029785188 @default.
- W2981365785 cites W2030897839 @default.
- W2981365785 cites W2040214100 @default.
- W2981365785 cites W2040327353 @default.
- W2981365785 cites W2044352858 @default.
- W2981365785 cites W2045959839 @default.
- W2981365785 cites W2046948981 @default.
- W2981365785 cites W2051502996 @default.
- W2981365785 cites W2057786779 @default.
- W2981365785 cites W2058489244 @default.
- W2981365785 cites W2066469508 @default.
- W2981365785 cites W2069830090 @default.
- W2981365785 cites W2072306817 @default.
- W2981365785 cites W2074431873 @default.
- W2981365785 cites W2076159058 @default.
- W2981365785 cites W2076711719 @default.
- W2981365785 cites W2077534823 @default.
- W2981365785 cites W2078472628 @default.
- W2981365785 cites W2083835304 @default.
- W2981365785 cites W2084428196 @default.
- W2981365785 cites W2089744025 @default.
- W2981365785 cites W2093304538 @default.
- W2981365785 cites W2098076627 @default.
- W2981365785 cites W2107038109 @default.
- W2981365785 cites W2108201412 @default.
- W2981365785 cites W2112425781 @default.
- W2981365785 cites W2114040881 @default.
- W2981365785 cites W2119624960 @default.
- W2981365785 cites W2120088072 @default.
- W2981365785 cites W2127554597 @default.
- W2981365785 cites W2128120055 @default.
- W2981365785 cites W2132296982 @default.
- W2981365785 cites W2136623765 @default.
- W2981365785 cites W2144994329 @default.
- W2981365785 cites W2145760315 @default.
- W2981365785 cites W2146054400 @default.
- W2981365785 cites W2146363912 @default.
- W2981365785 cites W2148890339 @default.
- W2981365785 cites W2150269711 @default.
- W2981365785 cites W2151221308 @default.
- W2981365785 cites W2152231829 @default.
- W2981365785 cites W2154512403 @default.
- W2981365785 cites W2154733002 @default.
- W2981365785 cites W2165113979 @default.
- W2981365785 cites W2167241965 @default.
- W2981365785 cites W2171613528 @default.
- W2981365785 cites W2211544744 @default.
- W2981365785 cites W2220964946 @default.
- W2981365785 cites W2264511039 @default.
- W2981365785 cites W2275780989 @default.
- W2981365785 cites W2306540679 @default.
- W2981365785 cites W2408210064 @default.
- W2981365785 cites W2486890521 @default.
- W2981365785 cites W2594707272 @default.
- W2981365785 cites W2607445526 @default.
- W2981365785 cites W2726929203 @default.
- W2981365785 cites W2741454017 @default.
- W2981365785 cites W2743018412 @default.